HitPredict

Interactor 1: MEG11 (A6BM72)
Multiple epidermal growth factor-like domains protein 11 (Multiple EGF-like domains protein 11)
Gene: MEGF11

Interactor 2: SHAN3 (Q9BYB0)
SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2)
Gene: SHANK3

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.50	0.494

Property	Details
Experiments	21653829
Identification Methods	two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1044 Hs			1 1731
+	Hs
		254237 MEGF6_HUMAN (5-671): 1.77e-76: 277: 32.43		SHAN3_HUMAN (1-1731): 0: 596: 100.00
+	Hs
		980523 NOTC2_HUMAN (3-853): 1.75e-55: 213: 18.47		SHAN3_HUMAN (1-1731): 0: 596: 100.00
+	Hs
		1316311 NOTC3_HUMAN (142-965): 2.14e-51: 200: 17.85		SHAN3_HUMAN (1-1731): 0: 596: 100.00
+	Hs
		1316313 JAG2_HUMAN (475-947): 1.67e-21: 103: 16.63		SHAN3_HUMAN (1-1731): 0: 596: 100.00
+	Hs
		1296145 MEG10_HUMAN (922-1041): 3.02e-12: 73: 57.50		SHAN3_HUMAN (1-1731): 0: 596: 100.00
+	Hs
		804330 NOTC1_HUMAN (1-442): 6.93e-12: 72.3: 15.39		SHAN3_HUMAN (1-1731): 0: 596: 100.00
+	Hs
		166914 NOTC2_HUMAN (3-853): 1.75e-55: 213: 18.47		ANR28_HUMAN (27-335): 3.42e-77: 281: 16.48
+	Hs
		167042 NOTC3_HUMAN (142-965): 2.14e-51: 200: 17.85		ANR28_HUMAN (27-335): 3.42e-77: 281: 16.48
+	Hs
		980449 NOTC2_HUMAN (3-853): 1.75e-55: 213: 18.47		ANR44_HUMAN (2-151): 2.27e-20: 100: 14.01
+	Hs
		1237561 NOTC3_HUMAN (142-965): 2.14e-51: 200: 17.85		ANR44_HUMAN (2-151): 2.27e-20: 100: 14.01
+	Dm
		65546 NOTCH_DROME (1-362): 3.04e-16: 86.5: 13.37		A8JNM5_DROME (649-1691): 7.65e-24: 112: 11.17
+	Hs
		944122 JAG1_HUMAN (1-503): 8.85e-24: 110: 16.57		MIB1_HUMAN (129-324): 9.56e-15: 82: 32.50
+	Mm
		1193398 JAG1_MOUSE (466-932): 6.18e-23: 108: 17.02		MIB1_MOUSE (129-324): 1.56e-14: 81.6: 32.50
+	Ce
		81043 CED1_CAEEL (3-392): 9.23e-29: 126: 27.36		SHANK_CAEEL (1659-1728): 9.7e-09: 62.8: 42.86
+	Mm
		1193399 JAG2_MOUSE (475-947): 1.36e-21: 103: 16.28		MIB1_MOUSE (129-324): 1.56e-14: 81.6: 32.50
+	Hs
		804293 NOTC1_HUMAN (1-442): 6.93e-12: 72.3: 15.39		ANR44_HUMAN (2-151): 2.27e-20: 100: 14.01
+	Dm
		422915 NOTCH_DROME (1-362): 3.04e-16: 86.5: 13.37		MIB_DROME (134-324): 1.09e-12: 75.5: 32.31
+	Dm
		575654 SERR_DROME (521-830): 2.21e-11: 70.6: 19.94		MIB_DROME (134-324): 1.09e-12: 75.5: 32.31
+	Dm
		113976 M9PB30_DROME (517-1016): 8.66e-10: 65.3: 13.35		M9PB30_DROME (349-1110): 2.53e-09: 65.1: 11.73