HitPredict

Interactor 1: KS6B1 (P23443)
Ribosomal protein S6 kinase beta-1 (S6K-beta-1) (S6K1) (EC 2.7.11.1) (70 kDa ribosomal protein S6 kinase 1) (P70S6K1) (p70-S6K 1) (Ribosomal protein S6 kinase I) (Serine/threonine-protein kinase 14A) (p70 ribosomal S6 kinase alpha) (p70 S6 kinase alpha) (p70 S6K-alpha) (p70 S6KA)
Gene: RPS6KB1

Interactor 2: PDK1 (Q15118)
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 1) (PDH kinase 1)
Gene: PDK1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.651

Property	Details
Experiments	11733037, 16286006, 17110931
Identification Methods	pull down, anti tag coimmunoprecipitation, protein kinase assay
Interaction Type	direct interaction, physical association, phosphorylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0004672 - protein kinase activity GO:0005524 - ATP binding GO:0005739 - mitochondrion
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 525 Hs			1 436
+	Rn
		932095 KS6B1_RAT (8-525): 0: 573: 99.61		PDK1_RAT (1-436): 0: 684: 92.20
+	Hs
		682176 AKT2_HUMAN (3-416): 5.02e-151: 442: 38.66		PDK1_HUMAN (1-436): 0: 674: 100.00
+	Hs
		681855 AKT1_HUMAN (34-418): 1.81e-150: 440: 39.90		PDK1_HUMAN (1-436): 0: 674: 100.00
+	Hs
		408617 KPCB_HUMAN (35-422): 2.03e-146: 437: 36.92		PDK1_HUMAN (1-436): 0: 674: 100.00
+	Hs
		117006 SGK1_HUMAN (79-417): 5.26e-101: 312: 46.44		PDK1_HUMAN (1-436): 0: 674: 100.00
+	Hs
		1068035 SGK3_HUMAN (70-417): 5.67e-95: 299: 45.13		PDK1_HUMAN (1-436): 0: 674: 100.00