HitPredict

Interactor 1: JAK1 (P23458)
Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1)
Gene: JAK1

Interactor 2: IL3RB (P32927)
Cytokine receptor common subunit beta (CDw131) (GM-CSF/IL-3/IL-5 receptor common beta subunit) (CD antigen CD131)
Gene: CSF2RB

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	15194700, 21965659, 9516124
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0007259 - cell surface receptor signaling pathway via JAK-STAT GO:0019221 - cytokine-mediated signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1154 Hs			1 897
+	Mm
		69810 B1ASP2_MOUSE (1-1154): 0: 1021: 94.63		IL3B2_MOUSE (1-878): 0: 597: 56.88
+	Hs
		238368 JAK2_HUMAN (33-1153): 0: 799: 42.14		IL3RB_HUMAN (1-897): 0: 586: 100.00
+	Mm
		645934 JAK2_MOUSE (33-1153): 0: 778: 41.54		IL3B2_MOUSE (1-878): 0: 597: 56.88
+	Mm
		645936 JAK2_MOUSE (33-1153): 0: 778: 41.54		IL3RB_MOUSE (1-897): 0: 592: 56.17
+	Hs
		616811 JAK1_HUMAN (1-1154): 0: 1035: 100.00		I13R2_HUMAN (129-457): 4.88e-93: 300: 19.66
+	Hs
		616795 JAK1_HUMAN (1-1154): 0: 1035: 100.00		IL5RA_HUMAN (129-483): 1.22e-75: 255: 19.69
+	Hs
		616738 JAK1_HUMAN (1-1154): 0: 1035: 100.00		IL4RA_HUMAN (233-881): 1.57e-46: 181: 16.60
+	Hs
		616744 JAK1_HUMAN (1-1154): 0: 1035: 100.00		IL2RG_HUMAN (245-547): 1.1e-48: 179: 20.06
+	Hs
		616753 JAK1_HUMAN (1-1154): 0: 1035: 100.00		IL6RB_HUMAN (238-477): 3.46e-44: 174: 18.22
+	Hs
		616793 JAK1_HUMAN (1-1154): 0: 1035: 100.00		IL9R_HUMAN (236-664): 1.18e-44: 171: 13.98
+	Hs
		616869 JAK1_HUMAN (1-1154): 0: 1035: 100.00		IL21R_HUMAN (33-239): 1.81e-42: 165: 20.48
+	Hs
		540444 JAK1_HUMAN (1-1154): 0: 1035: 100.00		IL2RB_HUMAN (248-745): 2.62e-37: 150: 15.62
+	Hs
		238398 JAK2_HUMAN (33-1153): 0: 799: 42.14		IL5RA_HUMAN (129-483): 1.22e-75: 255: 19.69
+	Hs
		238348 JAK2_HUMAN (33-1153): 0: 799: 42.14		PRLR_HUMAN (238-732): 1.03e-48: 185: 15.21
+	Hs
		238358 JAK2_HUMAN (33-1153): 0: 799: 42.14		IL4RA_HUMAN (233-881): 1.57e-46: 181: 16.60
+	Hs
		238367 JAK2_HUMAN (33-1153): 0: 799: 42.14		IL2RG_HUMAN (245-547): 1.1e-48: 179: 20.06
+	Hs
		238374 JAK2_HUMAN (33-1153): 0: 799: 42.14		IL6RB_HUMAN (238-477): 3.46e-44: 174: 18.22
+	Hs
		238353 JAK2_HUMAN (33-1153): 0: 799: 42.14		EPOR_HUMAN (245-684): 4.09e-38: 151: 18.36
+	Hs
		238343 JAK2_HUMAN (33-1153): 0: 799: 42.14		IL2RB_HUMAN (248-745): 2.62e-37: 150: 15.62
+	Mm
		540270 JAK2_MOUSE (33-1153): 0: 778: 41.54		EPOR_MOUSE (216-630): 1.13e-39: 156: 17.10