HitPredict

Interactor 1: JAK1 (P23458)
Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1)
Gene: JAK1

Interactor 2: IL6RB (P40189)
Interleukin-6 receptor subunit beta (IL-6 receptor subunit beta) (IL-6R subunit beta) (IL-6R-beta) (IL-6RB) (CDw130) (Interleukin-6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin-M receptor subunit alpha) (CD antigen CD130)
Gene: IL6ST

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	1.00	0.907

Property	Details
Experiments	11468294, 9388212, 11742534, 21220115
Identification Methods	affinity chromatography technology, pull down, experimental interaction detection, ion exchange chromatography, molecular sieving, transmission electron microscopy, coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~fn3
Common GO terms	GO:0005886 - plasma membrane GO:0019221 - cytokine-mediated signaling pathway GO:0038154 - interleukin-11-mediated signaling pathway GO:0070102 - interleukin-6-mediated signaling pathway GO:0072540 - T-helper 17 cell lineage commitment
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1154 Hs			1 918
+	Hs
		238374 JAK2_HUMAN (33-1153): 0: 799: 42.14		IL6RB_HUMAN (1-918): 0: 623: 100.00
+	Hs
		616859 JAK1_HUMAN (1-1154): 0: 1035: 100.00		OSMR_HUMAN (30-841): 8.5e-104: 347: 19.17
+	Hs
		616858 JAK1_HUMAN (1-1154): 0: 1035: 100.00		CSF3R_HUMAN (1-818): 1.84e-103: 342: 24.91
+	Mm
		960491 JAK2_MOUSE (33-1153): 0: 778: 41.54		IL6RB_MOUSE (1-918): 0: 574: 77.04
+	Hs
		616824 JAK1_HUMAN (1-1154): 0: 1035: 100.00		I27RA_HUMAN (139-709): 6.59e-54: 200: 19.83
+	Hs
		238434 JAK2_HUMAN (33-1153): 0: 799: 42.14		I12R2_HUMAN (10-848): 3.46e-89: 304: 20.07
+	Mm
		956337 JAK2_MOUSE (33-1153): 0: 778: 41.54		I12R2_MOUSE (1-849): 2.67e-88: 302: 19.84
+	Hs
		238348 JAK2_HUMAN (33-1153): 0: 799: 42.14		PRLR_HUMAN (124-351): 1.32e-50: 190: 25.83
+	Mm
		995942 JAK2_MOUSE (33-1153): 0: 778: 41.54		PRLR_MOUSE (115-336): 4.67e-52: 195: 27.90
+	Hs
		442787 HCK_HUMAN (853-1152): 4.44e-92: 307: 31.56		IL6RB_HUMAN (1-918): 0: 623: 100.00
+	Hs
		238382 JAK2_HUMAN (33-1153): 0: 799: 42.14		LEPR_HUMAN (295-801): 5.68e-14: 78.5: 12.94
+	Mm
		817305 JAK2_MOUSE (33-1153): 0: 778: 41.54		LEPR_MOUSE (4-824): 4.33e-15: 82.3: 13.77
+	Mm
		411919 LCK_MOUSE (833-1153): 6.52e-97: 319: 29.50		CSF3R_MOUSE (1-793): 1.35e-98: 329: 22.33
+	Mm
		56907 FYN_MOUSE (843-1151): 8.15e-96: 318: 27.74		PTPRF_MOUSE (32-733): 3.86e-85: 301: 15.40
+	Hs
		411565 LCK_HUMAN (833-1153): 1.23e-96: 319: 30.44		PTPRF_HUMAN (32-733): 1.82e-83: 296: 14.38
+	Hs
		411959 FYN_HUMAN (843-1151): 5.82e-96: 318: 27.74		PTPRF_HUMAN (32-733): 1.82e-83: 296: 14.38
+	Dm
		337644 ABL_DROME (868-1154): 1.63e-94: 334: 32.99		LAR_DROME (115-849): 8.92e-58: 219: 11.42
+	Hs
		412016 FYN_HUMAN (843-1151): 5.82e-96: 318: 27.74		PTPRD_HUMAN (1-897): 2.19e-59: 223: 11.86
+	Hs
		337354 ABL1_HUMAN (833-1154): 3.22e-95: 331: 29.72		CNTFR_HUMAN (39-326): 4.17e-50: 183: 22.11
+	Hs
		412029 FYN_HUMAN (843-1151): 5.82e-96: 318: 27.74		CNTFR_HUMAN (39-326): 4.17e-50: 183: 22.11