HitPredict

Interactor 1: JAK1 (P23458)
Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1)
Gene: JAK1

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: dip

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.780

Property	Details
Experiments	11527382, 8536716
Identification Methods	affinity chromatography technology, pull down, genetic interference
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	FERM_F1~SH2, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005768 - endosome GO:0005829 - cytosol GO:0005886 - plasma membrane and 1 others more... GO:0019903 - protein phosphatase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1154 Hs			1 217
+	Hs
		337349 JAK1_HUMAN (1-1154): 0: 1035: 100.00		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		616759 JAK1_HUMAN (1-1154): 0: 1035: 100.00		ABL2_HUMAN (4-139): 9.61e-22: 94.7: 34.04
+	Hs
		412015 JAK1_HUMAN (1-1154): 0: 1035: 100.00		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		238395 JAK2_HUMAN (33-1153): 0: 799: 42.14		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		238346 JAK2_HUMAN (33-1153): 0: 799: 42.14		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		238345 JAK2_HUMAN (33-1153): 0: 799: 42.14		VAV_HUMAN (2-60): 8.95e-15: 74.6: 42.37
+	Hs
		238330 JAK2_HUMAN (33-1153): 0: 799: 42.14		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		238332 JAK2_HUMAN (33-1153): 0: 799: 42.14		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Hs
		238342 JAK2_HUMAN (33-1153): 0: 799: 42.14		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Mm
		980968 JAK2_MOUSE (33-1153): 0: 778: 41.54		YES_MOUSE (161-215): 4.35e-12: 66.5: 28.07
+	Mm
		403446 JAK2_MOUSE (33-1153): 0: 778: 41.54		SRC_MOUSE (161-215): 3.76e-11: 63.8: 31.58
+	Dm
		337641 ABL_DROME (868-1154): 1.63e-94: 334: 32.99		ABL_DROME (4-135): 1e-22: 97.4: 37.68
+	Mm
		337637 ABL1_MOUSE (833-1154): 1.17e-95: 332: 29.41		NCK1_MOUSE (5-145): 8.99e-23: 96.3: 33.14
+	Mm
		337615 ABL1_MOUSE (833-1154): 1.17e-95: 332: 29.41		ABL1_MOUSE (4-139): 4.07e-22: 95.9: 35.46
+	Hs
		337293 ABL1_HUMAN (833-1154): 3.22e-95: 331: 29.72		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		337333 ABL1_HUMAN (833-1154): 3.22e-95: 331: 29.72		VAV_HUMAN (2-60): 8.95e-15: 74.6: 42.37
+	Hs
		337307 ABL1_HUMAN (833-1154): 3.22e-95: 331: 29.72		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		337315 ABL1_HUMAN (833-1154): 3.22e-95: 331: 29.72		HCK_HUMAN (120-215): 1.21e-12: 68.1: 19.39
+	Hs
		337329 ABL1_HUMAN (833-1154): 3.22e-95: 331: 29.72		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Hs
		275157 ABL1_HUMAN (833-1154): 3.22e-95: 331: 29.72		GRAP2_HUMAN (3-55): 1.58e-10: 61.3: 39.62