HitPredict

Interactor 1: JAK1 (P23458)
Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1)
Gene: JAK1

Interactor 2: SPTN1 (Q13813)
Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit)
Gene: SPTAN1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	30021884
Identification Methods	proximity labelling technology, cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1154 Hs			1 2472
+	Hs
		337470 ABL1_HUMAN (833-1154): 3.22e-95: 331: 29.72		SPTN1_HUMAN (1-2472): 0: 714: 100.00
+	Hs
		411715 LCK_HUMAN (833-1153): 1.23e-96: 319: 30.44		SPTN1_HUMAN (1-2472): 0: 714: 100.00
+	Hs
		433753 LYN_HUMAN (821-1152): 1.64e-90: 302: 28.23		SPTN1_HUMAN (1-2472): 0: 714: 100.00
+	Hs
		337296 ABL1_HUMAN (833-1154): 3.22e-95: 331: 29.72		SPTA1_HUMAN (1-2472): 2.98e-159: 552: 54.81
+	Hs
		164551 LCK_HUMAN (833-1153): 1.23e-96: 319: 30.44		SPTN2_HUMAN (141-1932): 1.25e-65: 250: 20.41
+	Hs
		164555 LYN_HUMAN (821-1152): 1.64e-90: 302: 28.23		SPTN2_HUMAN (141-1932): 1.25e-65: 250: 20.41
+	Hs
		297808 LYN_HUMAN (821-1152): 1.64e-90: 302: 28.23		K0754_HUMAN (1-1482): 9.32e-58: 225: 14.65
+	Hs
		411676 LCK_HUMAN (833-1153): 1.23e-96: 319: 30.44		SPTB2_HUMAN (2-1043): 1.4e-42: 174: 20.52
+	Hs
		411724 LCK_HUMAN (833-1153): 1.23e-96: 319: 30.44		GOGB1_HUMAN (2-1186): 3.65e-38: 160: 10.57
+	Hs
		433700 LYN_HUMAN (821-1152): 1.64e-90: 302: 28.23		SPTB2_HUMAN (2-1043): 1.4e-42: 174: 20.52
+	Hs
		411682 LCK_HUMAN (833-1153): 1.23e-96: 319: 30.44		DYST_HUMAN (5-2410): 1.41e-35: 152: 10.59
+	Hs
		433710 LYN_HUMAN (821-1152): 1.64e-90: 302: 28.23		DYST_HUMAN (5-2410): 1.41e-35: 152: 10.59
+	Hs
		411889 LCK_HUMAN (833-1153): 1.23e-96: 319: 30.44		MACF1_HUMAN (9-1261): 9.1e-18: 93.6: 12.48
+	Hs
		521454 SRC_HUMAN (868-1151): 7e-99: 326: 31.23		ACTN1_HUMAN (1862-2210): 3.16e-11: 71.2: 22.25
+	Hs
		434078 LYN_HUMAN (821-1152): 1.64e-90: 302: 28.23		MACF1_HUMAN (9-1261): 9.1e-18: 93.6: 12.48
+	Hs
		211480 SRC_HUMAN (868-1151): 7e-99: 326: 31.23		ACTN4_HUMAN (1843-2219): 1.15e-09: 66.2: 20.15
+	Hs
		974084 NTRK2_HUMAN (613-853): 8.97e-17: 87.8: 28.14		DYST_HUMAN (5-2410): 1.41e-35: 152: 10.59
+	Hs
		508011 FGFR1_HUMAN (566-873): 6e-15: 82: 24.18		PLEC_HUMAN (16-1253): 4.4e-31: 137: 9.18
+	Hs
		384183 NTRK1_HUMAN (578-853): 2.13e-14: 80.1: 25.17		ACTN1_HUMAN (1862-2210): 3.16e-11: 71.2: 22.25
+	Hs
		211458 NTRK1_HUMAN (578-853): 2.13e-14: 80.1: 25.17		ACTN4_HUMAN (1843-2219): 1.15e-09: 66.2: 20.15