HitPredict

Interactor 1: JAK1 (P23458)
Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1)
Gene: JAK1

Interactor 2: I13R2 (Q14627)
Interleukin-13 receptor subunit alpha-2 (IL-13 receptor subunit alpha-2) (IL-13R subunit alpha-2) (IL-13R-alpha-2) (IL-13RA2) (Interleukin-13-binding protein) (CD antigen CD213a2)
Gene: IL13RA2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0019221 - cytokine-mediated signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1154 Hs			1 380
+	Hs
		616795 JAK1_HUMAN (1-1154): 0: 1035: 100.00		IL5RA_HUMAN (11-374): 1.63e-68: 223: 24.34
+	Hs
		616744 JAK1_HUMAN (1-1154): 0: 1035: 100.00		IL2RG_HUMAN (116-372): 9.76e-50: 173: 22.47
+	Hs
		616869 JAK1_HUMAN (1-1154): 0: 1035: 100.00		IL21R_HUMAN (141-371): 1.04e-46: 168: 16.46
+	Mm
		69809 B1ASP2_MOUSE (1-1154): 0: 1021: 94.63		IL3RA_MOUSE (27-374): 3.56e-46: 164: 17.59
+	Hs
		616870 JAK1_HUMAN (1-1154): 0: 1035: 100.00		CRLF2_HUMAN (141-332): 3.19e-39: 145: 19.07
+	Hs
		616858 JAK1_HUMAN (1-1154): 0: 1035: 100.00		CSF3R_HUMAN (134-345): 1.62e-21: 98.4: 20.09
+	Hs
		616859 JAK1_HUMAN (1-1154): 0: 1035: 100.00		OSMR_HUMAN (140-361): 1.05e-18: 89.9: 15.65
+	Hs
		616746 JAK1_HUMAN (1-1154): 0: 1035: 100.00		IL3RB_HUMAN (127-336): 8.67e-17: 84.1: 15.22
+	Hs
		500945 JAK1_HUMAN (1-1154): 0: 1035: 100.00		GHR_HUMAN (115-374): 1e-16: 83.7: 17.18
+	Hs
		540444 JAK1_HUMAN (1-1154): 0: 1035: 100.00		IL2RB_HUMAN (142-363): 4.16e-16: 81.8: 15.68
+	Hs
		616753 JAK1_HUMAN (1-1154): 0: 1035: 100.00		IL6RB_HUMAN (48-374): 4.53e-15: 78.7: 12.05
+	Mm
		69810 B1ASP2_MOUSE (1-1154): 0: 1021: 94.63		IL3B2_MOUSE (139-365): 4.07e-15: 79.1: 14.52
+	Hs
		238348 JAK2_HUMAN (33-1153): 0: 799: 42.14		PRLR_HUMAN (136-376): 2.91e-53: 188: 21.15
+	Hs
		238367 JAK2_HUMAN (33-1153): 0: 799: 42.14		IL2RG_HUMAN (116-372): 9.76e-50: 173: 22.47
+	Hs
		238353 JAK2_HUMAN (33-1153): 0: 799: 42.14		EPOR_HUMAN (129-343): 8.72e-32: 127: 16.17
+	Hs
		238368 JAK2_HUMAN (33-1153): 0: 799: 42.14		IL3RB_HUMAN (127-336): 8.67e-17: 84.1: 15.22
+	Hs
		238338 JAK2_HUMAN (33-1153): 0: 799: 42.14		GHR_HUMAN (115-374): 1e-16: 83.7: 17.18
+	Hs
		238382 JAK2_HUMAN (33-1153): 0: 799: 42.14		LEPR_HUMAN (142-328): 4.12e-16: 82.2: 16.83
+	Hs
		238343 JAK2_HUMAN (33-1153): 0: 799: 42.14		IL2RB_HUMAN (142-363): 4.16e-16: 81.8: 15.68
+	Hs
		238374 JAK2_HUMAN (33-1153): 0: 799: 42.14		IL6RB_HUMAN (48-374): 4.53e-15: 78.7: 12.05