HitPredict

Interactor 1: JAK1 (P23458)
Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1)
Gene: JAK1

Interactor 2: SHB (Q15464)
SH2 domain-containing adapter protein B
Gene: SHB

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	12200137
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	FERM_F1~SH2, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1154 Hs			1 509
+	Hs
		412015 JAK1_HUMAN (1-1154): 0: 1035: 100.00		FYN_HUMAN (280-506): 1.72e-53: 190: 15.32
+	Mm
		69808 B1ASP2_MOUSE (1-1154): 0: 1021: 94.63		SOCS5_MOUSE (26-489): 7.82e-58: 202: 15.11
+	Hs
		616783 JAK1_HUMAN (1-1154): 0: 1035: 100.00		GRB2_HUMAN (349-507): 2.61e-46: 162: 15.63
+	Hs
		616759 JAK1_HUMAN (1-1154): 0: 1035: 100.00		ABL2_HUMAN (354-487): 6.99e-36: 144: 26.12
+	Hs
		337349 JAK1_HUMAN (1-1154): 0: 1035: 100.00		ABL1_HUMAN (354-507): 1.09e-35: 143: 24.03
+	Hs
		145961 JAK2_HUMAN (33-1153): 0: 799: 42.14		SH2B2_HUMAN (56-507): 1.2e-64: 223: 13.94
+	Hs
		238363 JAK2_HUMAN (33-1153): 0: 799: 42.14		SHC1_HUMAN (105-508): 5.28e-65: 222: 17.27
+	Hs
		238342 JAK2_HUMAN (33-1153): 0: 799: 42.14		SRC_HUMAN (264-488): 5.65e-61: 211: 18.57
+	Mm
		957236 JAK2_MOUSE (33-1153): 0: 778: 41.54		SHC1_MOUSE (105-508): 5.58e-66: 225: 17.12
+	Mm
		403446 JAK2_MOUSE (33-1153): 0: 778: 41.54		SRC_MOUSE (264-488): 1.12e-63: 218: 18.64
+	Hs
		238346 JAK2_HUMAN (33-1153): 0: 799: 42.14		NCK1_HUMAN (157-504): 3.1e-55: 191: 14.25
+	Hs
		238330 JAK2_HUMAN (33-1153): 0: 799: 42.14		FYN_HUMAN (280-506): 1.72e-53: 190: 15.32
+	Mm
		222647 JAK2_MOUSE (33-1153): 0: 778: 41.54		SOCS5_MOUSE (26-489): 7.82e-58: 202: 15.11
+	Mm
		980968 JAK2_MOUSE (33-1153): 0: 778: 41.54		YES_MOUSE (343-488): 6.44e-53: 189: 23.53
+	Hs
		238395 JAK2_HUMAN (33-1153): 0: 799: 42.14		GRB2_HUMAN (349-507): 2.61e-46: 162: 15.63
+	Mm
		337637 ABL1_MOUSE (833-1154): 1.17e-95: 332: 29.41		NCK1_MOUSE (157-504): 4.76e-55: 191: 14.80
+	Dm
		337641 ABL_DROME (868-1154): 1.63e-94: 334: 32.99		ABL_DROME (332-507): 3.08e-50: 187: 26.55
+	Hs
		337293 ABL1_HUMAN (833-1154): 3.22e-95: 331: 29.72		ABL1_HUMAN (354-507): 1.09e-35: 143: 24.03
+	Mm
		337615 ABL1_MOUSE (833-1154): 1.17e-95: 332: 29.41		ABL1_MOUSE (354-507): 2.92e-35: 142: 24.03
+	Hs
		275157 ABL1_HUMAN (833-1154): 3.22e-95: 331: 29.72		GRAP2_HUMAN (354-490): 4.56e-18: 87.3: 24.64