HitPredict

Interactor 1: JAK1 (P23458)
Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1)
Gene: JAK1

Interactor 2: RN125 (Q96EQ8)
E3 ubiquitin-protein ligase RNF125 (EC 2.3.2.27) (RING finger protein 125) (T-cell RING activation protein 1) (TRAC-1)
Gene: RNF125

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.50	0.533

Property	Details
Experiments	26027934, 35710093
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1154 Hs			1 232
+	Hs
		616851 JAK1_HUMAN (1-1154): 0: 1035: 100.00		TRI11_HUMAN (22-215): 2.41e-33: 126: 15.50
+	Hs
		536729 JAK1_HUMAN (1-1154): 0: 1035: 100.00		TRI27_HUMAN (22-228): 7.77e-33: 125: 15.49
+	Hs
		238447 JAK2_HUMAN (33-1153): 0: 799: 42.14		TRAF6_HUMAN (6-175): 2.58e-26: 108: 21.39
+	Hs
		238422 JAK2_HUMAN (33-1153): 0: 799: 42.14		LNX1_HUMAN (28-142): 7.17e-24: 101: 24.17
+	Hs
		337563 ABL1_HUMAN (833-1154): 3.22e-95: 331: 29.72		TRI39_HUMAN (28-229): 3.66e-38: 140: 16.90
+	Hs
		523138 SRC_HUMAN (868-1151): 7e-99: 326: 31.23		TRIM7_HUMAN (9-228): 5.54e-39: 142: 13.58
+	Hs
		412363 FYN_HUMAN (843-1151): 5.82e-96: 318: 27.74		TRI39_HUMAN (28-229): 3.66e-38: 140: 16.90
+	Hs
		522953 SRC_HUMAN (868-1151): 7e-99: 326: 31.23		TRAF3_HUMAN (5-175): 4.42e-33: 127: 19.89
+	Hs
		433465 YES_HUMAN (868-1151): 1.52e-97: 322: 30.53		TRIM5_HUMAN (24-229): 2.94e-33: 126: 15.81
+	Hs
		411890 LCK_HUMAN (833-1153): 1.23e-96: 319: 30.44		TRI35_HUMAN (18-229): 2.74e-32: 124: 12.67
+	Hs
		411977 FYN_HUMAN (843-1151): 5.82e-96: 318: 27.74		TRI27_HUMAN (22-228): 7.77e-33: 125: 15.49
+	Hs
		337607 ABL1_HUMAN (833-1154): 3.22e-95: 331: 29.72		TRAF6_HUMAN (6-175): 2.58e-26: 108: 21.39
+	Hs
		523227 SRC_HUMAN (868-1151): 7e-99: 326: 31.23		TRAF6_HUMAN (6-175): 2.58e-26: 108: 21.39
+	Mm
		403426 SRC_MOUSE (868-1151): 1.36e-97: 322: 30.88		TRAF6_MOUSE (6-174): 3.2e-27: 110: 22.67
+	Hs
		442773 HCK_HUMAN (853-1152): 4.44e-92: 307: 31.56		TRI27_HUMAN (22-228): 7.77e-33: 125: 15.49
+	Hs
		433514 YES_HUMAN (868-1151): 1.52e-97: 322: 30.53		TRAF6_HUMAN (6-175): 2.58e-26: 108: 21.39
+	Hs
		523076 SRC_HUMAN (868-1151): 7e-99: 326: 31.23		LNX1_HUMAN (28-142): 7.17e-24: 101: 24.17
+	Hs
		412424 FYN_HUMAN (843-1151): 5.82e-96: 318: 27.74		TRAF6_HUMAN (6-175): 2.58e-26: 108: 21.39
+	Hs
		433918 LYN_HUMAN (821-1152): 1.64e-90: 302: 28.23		RN138_HUMAN (21-222): 4.17e-34: 124: 26.25
+	Dm
		574899 FER_DROME (832-1153): 1.26e-83: 300: 29.50		Q9VJW5_DROME (37-120): 1.46e-12: 67.4: 27.47