HitPredict

Interactor 1: JAK1 (P23458)
Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1)
Gene: JAK1

Interactor 2: OSMR (Q99650)
Oncostatin-M-specific receptor subunit beta (Interleukin-31 receptor subunit beta) (IL-31 receptor subunit beta) (IL-31R subunit beta) (IL-31R-beta) (IL-31RB)
Gene: OSMR

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.64	1.00	0.802

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~fn3
Common GO terms	GO:0005886 - plasma membrane GO:0019221 - cytokine-mediated signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1154 Hs			1 979
+	Hs
		616858 JAK1_HUMAN (1-1154): 0: 1035: 100.00		CSF3R_HUMAN (156-881): 5.37e-109: 359: 19.32
+	Hs
		616753 JAK1_HUMAN (1-1154): 0: 1035: 100.00		IL6RB_HUMAN (147-827): 2.76e-106: 354: 21.57
+	Hs
		238434 JAK2_HUMAN (33-1153): 0: 799: 42.14		I12R2_HUMAN (154-932): 5.27e-119: 386: 20.79
+	Hs
		616824 JAK1_HUMAN (1-1154): 0: 1035: 100.00		I27RA_HUMAN (247-890): 1.52e-29: 127: 18.66
+	Hs
		238374 JAK2_HUMAN (33-1153): 0: 799: 42.14		IL6RB_HUMAN (147-827): 2.76e-106: 354: 21.57
+	Mm
		956337 JAK2_MOUSE (33-1153): 0: 778: 41.54		I12R2_MOUSE (154-837): 1.55e-114: 375: 20.16
+	Mm
		960491 JAK2_MOUSE (33-1153): 0: 778: 41.54		IL6RB_MOUSE (143-823): 1.9e-102: 343: 20.65
+	Hs
		238382 JAK2_HUMAN (33-1153): 0: 799: 42.14		LEPR_HUMAN (125-612): 6.06e-29: 127: 19.05
+	Mm
		817305 JAK2_MOUSE (33-1153): 0: 778: 41.54		LEPR_MOUSE (48-623): 2.11e-34: 144: 18.67
+	Hs
		442875 HCK_HUMAN (853-1152): 4.44e-92: 307: 31.56		CSF3R_HUMAN (156-881): 5.37e-109: 359: 19.32
+	Hs
		433961 LYN_HUMAN (821-1152): 1.64e-90: 302: 28.23		CSF3R_HUMAN (156-881): 5.37e-109: 359: 19.32
+	Hs
		442787 HCK_HUMAN (853-1152): 4.44e-92: 307: 31.56		IL6RB_HUMAN (147-827): 2.76e-106: 354: 21.57
+	Mm
		411919 LCK_MOUSE (833-1153): 6.52e-97: 319: 29.50		CSF3R_MOUSE (156-896): 1.57e-98: 330: 16.56
+	Dm
		337644 ABL_DROME (868-1154): 1.63e-94: 334: 32.99		LAR_DROME (3-911): 1.84e-63: 237: 10.62
+	Hs
		411565 LCK_HUMAN (833-1153): 1.23e-96: 319: 30.44		PTPRF_HUMAN (3-533): 1.16e-36: 152: 10.04
+	Hs
		411959 FYN_HUMAN (843-1151): 5.82e-96: 318: 27.74		PTPRF_HUMAN (3-533): 1.16e-36: 152: 10.04
+	Hs
		433804 LYN_HUMAN (821-1152): 1.64e-90: 302: 28.23		SDK2_HUMAN (1-617): 3.38e-36: 151: 11.33
+	Hs
		412016 FYN_HUMAN (843-1151): 5.82e-96: 318: 27.74		PTPRD_HUMAN (424-977): 2.07e-25: 116: 8.71
+	Mm
		56907 FYN_MOUSE (843-1151): 8.15e-96: 318: 27.74		PTPRF_MOUSE (546-967): 3.49e-11: 69.8: 9.95
+	Hs
		434019 LYN_HUMAN (821-1152): 1.64e-90: 302: 28.23		ROBO2_HUMAN (419-977): 2.77e-09: 63.6: 8.81