HitPredict

Interactor 1: JAK1 (P23458)
Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1)
Gene: JAK1

Interactor 2: IL21R (Q9HBE5)
Interleukin-21 receptor (IL-21 receptor) (IL-21R) (Novel interleukin receptor) (CD antigen CD360)
Gene: IL21R

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	11016959
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0019221 - cytokine-mediated signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1154 Hs			1 538
+	Hs
		500945 JAK1_HUMAN (1-1154): 0: 1035: 100.00		GHR_HUMAN (12-460): 3.43e-77: 257: 13.03
+	Hs
		562506 JAK1_HUMAN (1-1154): 0: 1035: 100.00		IL7RA_HUMAN (97-436): 3.95e-71: 236: 18.73
+	Hs
		616795 JAK1_HUMAN (1-1154): 0: 1035: 100.00		IL5RA_HUMAN (1-285): 3.73e-55: 193: 16.83
+	Hs
		616744 JAK1_HUMAN (1-1154): 0: 1035: 100.00		IL2RG_HUMAN (12-354): 4.39e-54: 188: 15.47
+	Hs
		616811 JAK1_HUMAN (1-1154): 0: 1035: 100.00		I13R2_HUMAN (3-264): 1.39e-53: 187: 15.30
+	Hs
		616870 JAK1_HUMAN (1-1154): 0: 1035: 100.00		CRLF2_HUMAN (5-341): 8.81e-54: 187: 20.44
+	Hs
		616738 JAK1_HUMAN (1-1154): 0: 1035: 100.00		IL4RA_HUMAN (9-320): 3.7e-48: 180: 22.01
+	Hs
		616793 JAK1_HUMAN (1-1154): 0: 1035: 100.00		IL9R_HUMAN (9-437): 5.57e-49: 179: 20.65
+	Hs
		616753 JAK1_HUMAN (1-1154): 0: 1035: 100.00		IL6RB_HUMAN (19-237): 1.14e-41: 162: 16.59
+	Hs
		540444 JAK1_HUMAN (1-1154): 0: 1035: 100.00		IL2RB_HUMAN (19-469): 2.45e-42: 160: 19.83
+	Mm
		562596 JAK1_MOUSE (1-1154): 0: 1010: 93.86		IL7RA_MOUSE (97-436): 3.14e-50: 180: 16.43
+	Hs
		616858 JAK1_HUMAN (1-1154): 0: 1035: 100.00		CSF3R_HUMAN (20-238): 5.85e-32: 132: 13.48
+	Hs
		616859 JAK1_HUMAN (1-1154): 0: 1035: 100.00		OSMR_HUMAN (20-242): 6.78e-31: 129: 14.66
+	Hs
		445715 JAK1_HUMAN (1-1154): 0: 1035: 100.00		IL6RA_HUMAN (21-231): 4.86e-30: 124: 19.82
+	Hs
		616746 JAK1_HUMAN (1-1154): 0: 1035: 100.00		IL3RB_HUMAN (21-227): 1.45e-13: 75.8: 19.44
+	Mm
		69810 B1ASP2_MOUSE (1-1154): 0: 1021: 94.63		IL3B2_MOUSE (21-227): 7.42e-15: 79.7: 18.98
+	Hs
		238338 JAK2_HUMAN (33-1153): 0: 799: 42.14		GHR_HUMAN (12-460): 3.43e-77: 257: 13.03
+	Hs
		238348 JAK2_HUMAN (33-1153): 0: 799: 42.14		PRLR_HUMAN (18-502): 4.75e-76: 253: 14.17
+	Hs
		238353 JAK2_HUMAN (33-1153): 0: 799: 42.14		EPOR_HUMAN (13-358): 6.42e-49: 178: 20.40
+	Hs
		238343 JAK2_HUMAN (33-1153): 0: 799: 42.14		IL2RB_HUMAN (19-469): 2.45e-42: 160: 19.83