HitPredict

Interactor 1: PTPRB (P23467)
Receptor-type tyrosine-protein phosphatase beta (Protein-tyrosine phosphatase beta) (R-PTP-beta) (EC 3.1.3.48) (Vascular endothelial protein tyrosine phosphatase) (VE-PTP)
Gene: PTPRB

Interactor 2: CTNB1 (P35222)
Catenin beta-1 (Beta-catenin)
Gene: CTNNB1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	19167335
Identification Methods	phosphatase assay
Interaction Type	dephosphorylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0045296 - cadherin binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1997 Hs			1 781
+	Hs
		576992 PTPRA_HUMAN (1687-1966): 2.17e-103: 353: 35.23		CTNB1_HUMAN (1-781): 0: 626: 100.00
+	Rn
		1145481 PTPRF_RAT (1637-1964): 2.19e-87: 320: 33.44		CTNB1_RAT (1-781): 0: 625: 99.74
+	Mm
		56908 PTPRF_MOUSE (1637-1964): 1.5e-87: 321: 33.13		CTNB1_MOUSE (1-781): 0: 624: 99.87
+	Hs
		489914 PTPRF_HUMAN (905-1707): 2.85e-67: 255: 10.82		CTNB1_HUMAN (1-781): 0: 626: 100.00
+	Hs
		441183 PTPRC_HUMAN (1703-1975): 3.32e-25: 117: 27.67		CTNB1_HUMAN (1-781): 0: 626: 100.00
+	Hs
		717127 PTPRO_HUMAN (41-479): 4.06e-24: 113: 14.46		CTNB1_HUMAN (1-781): 0: 626: 100.00
+	Hs
		617157 PTPRZ_HUMAN (1703-1976): 2.1e-23: 111: 30.96		CTNB1_HUMAN (1-781): 0: 626: 100.00
+	Hs
		617080 PTPRG_HUMAN (1727-1968): 6.3e-23: 109: 29.60		CTNB1_HUMAN (1-781): 0: 626: 100.00
+	Hs
		489895 PTPRF_HUMAN (905-1707): 2.85e-67: 255: 10.82		PLAK_HUMAN (8-752): 2.69e-158: 479: 67.42
+	Mm
		660881 PTPRM_MOUSE (476-1031): 5.65e-22: 106: 12.30		CTNB1_MOUSE (1-781): 0: 624: 99.87
+	Mm
		472764 PTPRQ_MOUSE (2-337): 4.78e-19: 97: 13.28		CTNB1_MOUSE (1-781): 0: 624: 99.87
+	Dm
		578796 Q9W4F5_DROME (13-877): 7.25e-61: 234: 15.78		ARM_DROME (1-780): 9.15e-160: 486: 64.49
+	Dm
		90970 E1JJE4_DROME (13-877): 1.43e-60: 232: 15.78		ARM_DROME (1-780): 9.15e-160: 486: 64.49
+	Hs
		717036 PTPRJ_HUMAN (1245-1617): 2.86e-16: 87.8: 15.75		CTNB1_HUMAN (1-781): 0: 626: 100.00
+	Hs
		717099 PTPRK_HUMAN (262-866): 9.73e-16: 85.8: 10.10		CTNB1_HUMAN (1-781): 0: 626: 100.00
+	Mm
		472765 PTPRQ_MOUSE (2-337): 4.78e-19: 97: 13.28		PLAK_MOUSE (8-752): 6.82e-156: 473: 66.62
+	Hs
		542300 PTPRJ_HUMAN (1245-1617): 2.86e-16: 87.8: 15.75		PLAK_HUMAN (8-752): 2.69e-158: 479: 67.42
+	Hs
		542330 PTPRK_HUMAN (262-866): 9.73e-16: 85.8: 10.10		PLAK_HUMAN (8-752): 2.69e-158: 479: 67.42
+	Dm
		561758 PTP69_DROME (265-616): 3.88e-13: 77.6: 14.85		ARM_DROME (1-780): 9.15e-160: 486: 64.49
+	Hs
		362959 FINC_HUMAN (1147-1761): 1.77e-33: 144: 15.13		IMA1_HUMAN (237-675): 3.54e-66: 231: 18.54