HitPredict

Interactor 1: PTPRB (P23467)
Receptor-type tyrosine-protein phosphatase beta (Protein-tyrosine phosphatase beta) (R-PTP-beta) (EC 3.1.3.48) (Vascular endothelial protein tyrosine phosphatase) (VE-PTP)
Gene: PTPRB

Interactor 2: TIE2 (Q02763)
Angiopoietin-1 receptor (EC 2.7.10.1) (Endothelial tyrosine kinase) (Tunica interna endothelial cell kinase) (Tyrosine kinase with Ig and EGF homology domains-2) (Tyrosine-protein kinase receptor TEK) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (p140 TEK) (CD antigen CD202b)
Gene: TEK

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	12237455, 19167335
Identification Methods	peptide array, phosphatase assay
Interaction Type	dephosphorylation reaction

Property	Details
Interacting Pfam domains	fn3~fn3, PK_Tyr_Ser-Thr~fn3, PK_Tyr_Ser-Thr~Y_phosphatase
Common GO terms	GO:0001525 - angiogenesis GO:0005886 - plasma membrane GO:0043235 - receptor complex
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1997 Hs			1 1124
+	Hs
		441193 PTPRC_HUMAN (1703-1975): 3.32e-25: 117: 27.67		TIE2_HUMAN (1-1124): 0: 1212: 100.00
+	Hs
		972332 PTPRO_HUMAN (41-479): 4.06e-24: 113: 14.46		TIE2_HUMAN (1-1124): 0: 1212: 100.00
+	Hs
		617103 PTPRG_HUMAN (1727-1968): 6.3e-23: 109: 29.60		TIE2_HUMAN (1-1124): 0: 1212: 100.00
+	Hs
		972322 PTPRJ_HUMAN (1245-1617): 2.86e-16: 87.8: 15.75		TIE2_HUMAN (1-1124): 0: 1212: 100.00
+	Hs
		972328 PTPRK_HUMAN (262-866): 9.73e-16: 85.8: 10.10		TIE2_HUMAN (1-1124): 0: 1212: 100.00
+	Hs
		441184 PTPRC_HUMAN (1703-1975): 3.32e-25: 117: 27.67		TIE1_HUMAN (14-1123): 0: 1031: 45.69
+	Hs
		617082 PTPRG_HUMAN (1727-1968): 6.3e-23: 109: 29.60		TIE1_HUMAN (14-1123): 0: 1031: 45.69
+	Hs
		725305 PTPRJ_HUMAN (1245-1617): 2.86e-16: 87.8: 15.75		TIE1_HUMAN (14-1123): 0: 1031: 45.69
+	Hs
		987281 COCA1_HUMAN (374-1717): 1.46e-83: 309: 11.03		TYRO3_HUMAN (351-1116): 2.69e-156: 489: 22.55
+	Hs
		616944 PTPRD_HUMAN (902-1709): 1.7e-69: 262: 12.33		EPHA8_HUMAN (519-1110): 2.23e-152: 483: 21.58
+	Hs
		434133 PTPRA_HUMAN (1687-1966): 2.17e-103: 353: 35.23		RET_HUMAN (830-1104): 6.46e-68: 251: 45.02
+	Hs
		665257 PTPRO_HUMAN (41-479): 4.06e-24: 113: 14.46		EPHA2_HUMAN (442-1123): 7.37e-153: 483: 22.10
+	Hs
		507980 PTPRS_HUMAN (2-201): 6.84e-11: 70: 12.73		FGFR1_HUMAN (362-1124): 2.97e-155: 484: 23.82
+	Dm
		337644 LAR_DROME (1706-1964): 5.02e-84: 310: 37.69		ABL_DROME (813-1098): 1.32e-56: 217: 38.85
+	Hs
		434120 PTPRF_HUMAN (905-1707): 2.85e-67: 255: 10.82		RET_HUMAN (830-1104): 6.46e-68: 251: 45.02
+	Hs
		600632 TITIN_HUMAN (903-1102): 2.88e-09: 65: 11.52		EPHA1_HUMAN (525-1123): 4.19e-118: 390: 23.40
+	Hs
		234508 DSCAM_HUMAN (2-661): 1.06e-64: 246: 12.72		MERTK_HUMAN (350-632): 2.4e-17: 89.7: 16.89
+	Dm
		337647 PTP99_DROME (1708-1933): 5.59e-15: 83.6: 26.84		ABL_DROME (813-1098): 1.32e-56: 217: 38.85
+	Dm
		337643 PTP69_DROME (265-616): 3.88e-13: 77.6: 14.85		ABL_DROME (813-1098): 1.32e-56: 217: 38.85