HitPredict

Interactor 1: PTPRB (P23467)
Receptor-type tyrosine-protein phosphatase beta (Protein-tyrosine phosphatase beta) (R-PTP-beta) (EC 3.1.3.48) (Vascular endothelial protein tyrosine phosphatase) (VE-PTP)
Gene: PTPRB

Interactor 2: MAGI3 (Q5TCQ9)
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 (Membrane-associated guanylate kinase inverted 3) (MAGI-3)
Gene: MAGI3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.740

Property	Details
Experiments	12615970
Identification Methods	two hybrid, affinity chromatography technology, pull down
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PDZ~fn3
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1997 Hs			1 1481
+	Rn
		88576 D3ZDA6_RAT (361-1681): 2.36e-108: 388: 10.71		MAGI3_RAT (1-1480): 0: 822: 84.84
+	Hs
		234530 DSCAM_HUMAN (2-661): 1.06e-64: 246: 12.72		MAGI3_HUMAN (1-1481): 0: 886: 100.00
+	Hs
		1136432 DSCL1_HUMAN (1-574): 4.63e-51: 202: 11.71		MAGI3_HUMAN (1-1481): 0: 886: 100.00
+	Hs
		234545 DSCAM_HUMAN (2-661): 1.06e-64: 246: 12.72		MAGI2_HUMAN (1-1356): 2.23e-159: 522: 40.55
+	Hs
		1199785 DSCL1_HUMAN (1-574): 4.63e-51: 202: 11.71		MAGI2_HUMAN (1-1356): 2.23e-159: 522: 40.55
+	Rn
		88569 D3ZDA6_RAT (361-1681): 2.36e-108: 388: 10.71		D3ZWS0_RAT (14-720): 3.41e-39: 162: 12.94
+	Rn
		88571 D3ZDA6_RAT (361-1681): 2.36e-108: 388: 10.71		MAGI2_RAT (308-1386): 4.83e-35: 148: 12.55
+	Rn
		88575 D3ZDA6_RAT (361-1681): 2.36e-108: 388: 10.71		DLG2_RAT (2-207): 4.15e-26: 118: 14.22
+	Rn
		88574 D3ZDA6_RAT (361-1681): 2.36e-108: 388: 10.71		DLG3_RAT (16-398): 1.03e-23: 110: 8.70
+	Hs
		577018 PTPRA_HUMAN (1687-1966): 2.17e-103: 353: 35.23		PTN13_HUMAN (83-1101): 5.15e-32: 139: 11.88
+	Rn
		88572 D3ZDA6_RAT (361-1681): 2.36e-108: 388: 10.71		DLG4_RAT (13-291): 2.72e-14: 80: 9.96
+	Rn
		88573 D3ZDA6_RAT (361-1681): 2.36e-108: 388: 10.71		MAGI1_RAT (981-1378): 3.21e-13: 77: 13.63
+	Rn
		957054 PTPRF_RAT (1637-1964): 2.19e-87: 320: 33.44		GRIP1_RAT (680-1469): 3.29e-25: 116: 11.35
+	Rn
		677796 Q66HJ7_RAT (1687-1966): 1.81e-103: 354: 35.23		DLG4_RAT (13-291): 2.72e-14: 80: 9.96
+	Mm
		1143349 SDK2_MOUSE (456-1709): 5.41e-91: 332: 10.89		DLG4_MOUSE (19-236): 3.76e-14: 79.6: 12.05
+	Hs
		234509 DSCAM_HUMAN (2-661): 1.06e-64: 246: 12.72		PTN13_HUMAN (83-1101): 5.15e-32: 139: 11.88
+	Hs
		234511 DSCAM_HUMAN (2-661): 1.06e-64: 246: 12.72		DLG1_HUMAN (14-594): 2.26e-26: 119: 9.03
+	Hs
		234522 DSCAM_HUMAN (2-661): 1.06e-64: 246: 12.72		DLG2_HUMAN (20-162): 2.63e-14: 80.4: 18.24
+	Hs
		234499 DSCAM_HUMAN (2-661): 1.06e-64: 246: 12.72		DLG4_HUMAN (13-291): 3.17e-14: 80: 9.96
+	Hs
		1123250 SDK2_HUMAN (3-473): 6e-50: 198: 14.84		NHRF3_HUMAN (15-518): 1.23e-26: 118: 12.72