HitPredict

Interactor 1: PTPRE (P23469)
Receptor-type tyrosine-protein phosphatase epsilon (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon) (EC 3.1.3.48)
Gene: PTPRE

Interactor 2: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	18093973
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~Y_phosphatase
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 700 Hs			1 583
+	Hs
		576989 PTPRA_HUMAN (13-700): 0: 863: 66.52		SHC1_HUMAN (1-583): 0: 531: 100.00
+	Mm
		828096 PTPRE_MOUSE (1-700): 0: 860: 92.73		SHC1_MOUSE (1-583): 0: 527: 94.51
+	Mm
		69652 PTPRS_MOUSE (1-697): 0: 890: 40.99		ANS1B_MOUSE (39-364): 1.02e-45: 175: 17.86
+	Hs
		616962 PTPRD_HUMAN (1-697): 0: 883: 41.54		BMX_HUMAN (341-582): 1.11e-38: 153: 19.69
+	Hs
		208991 PTPRA_HUMAN (13-700): 0: 863: 66.52		NCK2_HUMAN (363-579): 5.31e-45: 165: 18.83
+	Hs
		489988 PTPRF_HUMAN (3-697): 0: 864: 42.21		SH2D3_HUMAN (333-582): 8.25e-40: 157: 23.55
+	Hs
		577024 PTPRA_HUMAN (13-700): 0: 863: 66.52		SHB_HUMAN (369-579): 2.01e-41: 158: 20.63
+	Hs
		576988 PTPRA_HUMAN (13-700): 0: 863: 66.52		P85A_HUMAN (300-581): 2.38e-38: 152: 15.31
+	Hs
		617047 PTPRE_HUMAN (1-700): 0: 885: 100.00		GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48
+	Hs
		577009 PTPRA_HUMAN (13-700): 0: 863: 66.52		GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48
+	Mm
		574006 PTPRA_MOUSE (26-700): 0: 842: 64.10		GRB2_MOUSE (482-578): 3.54e-15: 76.8: 30.48
+	Hs
		146925 PTPRT_HUMAN (81-693): 0: 727: 37.96		GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48
+	Mm
		420370 PTPRC_MOUSE (120-423): 1.56e-71: 255: 28.61		VAV_MOUSE (163-579): 6.29e-54: 198: 11.54
+	Hs
		924529 PTPRJ_HUMAN (409-695): 5.77e-113: 371: 36.81		GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48
+	Hs
		573654 PTN1_HUMAN (425-700): 3.73e-109: 339: 26.35		GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48
+	Hs
		655375 PTPRK_HUMAN (122-398): 9.09e-62: 226: 32.39		P85A_HUMAN (300-581): 2.38e-38: 152: 15.31
+	Mm
		82788 PTPRZ_MOUSE (113-410): 6.14e-54: 203: 26.80		ANS1B_MOUSE (39-364): 1.02e-45: 175: 17.86
+	Mm
		420374 PTPRC_MOUSE (120-423): 1.56e-71: 255: 28.61		GRB2_MOUSE (482-578): 3.54e-15: 76.8: 30.48