HitPredict

Interactor 1: PTPRE (P23469)
Receptor-type tyrosine-protein phosphatase epsilon (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon) (EC 3.1.3.48)
Gene: PTPRE

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.81	1.00	0.903

Property	Details
Experiments	10490839, 27880917, 28330616, 33961781
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	SH2~Y_phosphatase
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 700 Hs			1 217
+	Hs
		577009 PTPRA_HUMAN (13-700): 0: 863: 66.52		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Mm
		574006 PTPRA_MOUSE (26-700): 0: 842: 64.10		GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54
+	Hs
		411565 PTPRF_HUMAN (3-697): 0: 864: 42.21		LCK_HUMAN (3-202): 3.69e-37: 137: 28.91
+	Hs
		412017 PTPRE_HUMAN (1-700): 0: 885: 100.00		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		146925 PTPRT_HUMAN (81-693): 0: 727: 37.96		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		412016 PTPRD_HUMAN (1-697): 0: 883: 41.54		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		433255 PTPRE_HUMAN (1-700): 0: 885: 100.00		YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91
+	Mm
		56907 PTPRF_MOUSE (3-697): 0: 869: 42.35		FYN_MOUSE (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		411959 PTPRF_HUMAN (3-697): 0: 864: 42.21		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		411997 PTPRA_HUMAN (13-700): 0: 863: 66.52		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Rn
		1144045 Q66HJ7_RAT (26-700): 0: 858: 67.21		FYN_RAT (161-215): 4.44e-14: 72.3: 31.58
+	Dm
		337644 LAR_DROME (2-698): 0: 831: 41.10		ABL_DROME (4-135): 1e-22: 97.4: 37.68
+	Hs
		522756 PTPRA_HUMAN (13-700): 0: 863: 66.52		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Rn
		1146020 Q66HJ7_RAT (26-700): 0: 858: 67.21		SRC_RAT (117-215): 2.55e-11: 64.2: 20.79
+	Mm
		574000 PTPRA_MOUSE (26-700): 0: 842: 64.10		FYN_MOUSE (161-215): 4.44e-14: 72.3: 31.58
+	Rn
		976063 PTPRA_RAT (26-700): 0: 843: 66.47		SRC_RAT (117-215): 2.55e-11: 64.2: 20.79
+	Mm
		403413 PTPRA_MOUSE (26-700): 0: 842: 64.10		SRC_MOUSE (161-215): 3.76e-11: 63.8: 31.58
+	Hs
		411597 PTPRG_HUMAN (11-695): 0: 745: 32.78		LCK_HUMAN (3-202): 3.69e-37: 137: 28.91
+	Hs
		617084 PTPRG_HUMAN (11-695): 0: 745: 32.78		CSK_HUMAN (2-139): 3.92e-24: 100: 36.24
+	Hs
		433579 PTPRG_HUMAN (11-695): 0: 745: 32.78		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47