Interactor 1: SP100 (P23497)
Nuclear autoantigen Sp-100 (Nuclear dot-associated Sp100 protein) (Speckled 100 kDa)
Gene: SP100

Interactor 2: SP100 (P23497)
Nuclear autoantigen Sp-100 (Nuclear dot-associated Sp100 protein) (Speckled 100 kDa)
Gene: SP100

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.90 1.00 0.953

The method score is based on:

Property Details
Experiments 25416956, 27107012, 32296183, 10212234, unassigned1304, 21880768
Identification Methods two hybrid, affinity chromatography technology, two hybrid array, barcode fusion genetics two hybrid, validated two hybrid, two hybrid prey pooling approach
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains HMG_box~HMG_box, HMG_box~HMG_box_2, HMG_box_2~HMG_box_2, SAND~SAND
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000723 - telomere maintenance
GO:0000781 - chromosome, telomeric region
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0003677 - DNA binding
and 34 others

more...

Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 879
Hs

1 879
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Last updated: 15 Jul 2024