HitPredict

Interactor 1: SP100 (P23497)
Nuclear autoantigen Sp-100 (Nuclear dot-associated Sp100 protein) (Speckled 100 kDa)
Gene: SP100

Interactor 2: ACTN2 (P35609)
Alpha-actinin-2 (Alpha-actinin skeletal muscle isoform 2) (F-actin cross-linking protein)
Gene: ACTN2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.77	0.60	0.683

Property	Details
Experiments	25416956, 25910212, 31515488
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, two hybrid bait and prey pooling approach, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0019904 - protein domain specific binding
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 879 Hs			1 894
+	Hs
		211529 SOX2_HUMAN (736-852): 3.75e-28: 117: 15.39		ACTN4_HUMAN (18-894): 0: 619: 77.89
+	Hs
		211490 UBF1_HUMAN (684-878): 1.22e-16: 86.7: 22.56		ACTN4_HUMAN (18-894): 0: 619: 77.89
+	Hs
		506811 SOX2_HUMAN (736-852): 3.75e-28: 117: 15.39		SPTB1_HUMAN (245-777): 2.92e-11: 69.7: 10.24
+	Hs
		164582 SOX2_HUMAN (736-852): 3.75e-28: 117: 15.39		SPTN2_HUMAN (250-805): 1.17e-09: 64.7: 10.73
+	Hs
		817925 SOX2_HUMAN (736-852): 3.75e-28: 117: 15.39		SPTB2_HUMAN (232-802): 2.32e-09: 63.5: 9.98