HitPredict

Interactor 1: SP100 (P23497)
Nuclear autoantigen Sp-100 (Nuclear dot-associated Sp100 protein) (Speckled 100 kDa)
Gene: SP100

Interactor 2: PHC1 (P78364)
Polyhomeotic-like protein 1 (hPH1) (Early development regulatory protein 1)
Gene: PHC1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.481

Property	Details
Experiments	25416956
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016604 - nuclear body GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 879 Hs			1 1004
+	Hs
		617314 SP100_HUMAN (1-852): 0: 720: 100.00		Q59GP6_HUMAN (1-1004): 5.13e-86: 302: 99.90
+	Hs
		617355 SP100_HUMAN (1-852): 0: 720: 100.00		LMBL3_HUMAN (750-1004): 1.75e-34: 144: 20.91
+	Hs
		617349 SP100_HUMAN (1-852): 0: 720: 100.00		CBP_HUMAN (236-907): 8.37e-09: 61.9: 8.86
+	Hs
		727934 SOX6_HUMAN (506-843): 1.88e-50: 193: 11.93		CHD7_HUMAN (112-659): 1.76e-12: 74.2: 8.70
+	Hs
		818357 SOX2_HUMAN (736-852): 3.75e-28: 117: 15.39		LMBL3_HUMAN (750-1004): 1.75e-34: 144: 20.91
+	Mm
		818734 SOX2_MOUSE (762-852): 1.25e-27: 116: 19.78		LMBL3_MOUSE (907-1004): 1.67e-27: 122: 35.24
+	Hs
		449782 HMGB1_HUMAN (675-847): 9.29e-36: 136: 76.30		CBP_HUMAN (236-907): 8.37e-09: 61.9: 8.86
+	Hs
		881831 SOX10_HUMAN (707-872): 1.33e-28: 122: 18.68		CHD7_HUMAN (112-659): 1.76e-12: 74.2: 8.70
+	Hs
		1332326 SOX17_HUMAN (735-854): 4.58e-28: 119: 18.33		CHD7_HUMAN (112-659): 1.76e-12: 74.2: 8.70
+	Hs
		818550 SOX2_HUMAN (736-852): 3.75e-28: 117: 15.39		CHD7_HUMAN (112-659): 1.76e-12: 74.2: 8.70
+	Hs
		1243843 SOX17_HUMAN (735-854): 4.58e-28: 119: 18.33		KMT2C_HUMAN (278-935): 1.09e-10: 68.5: 8.60
+	Mm
		57186 Q60I23_MOUSE (762-852): 1.11e-27: 116: 19.78		CHD7_MOUSE (238-942): 1.27e-11: 71.2: 9.09
+	Hs
		152619 SOX10_HUMAN (707-872): 1.33e-28: 122: 18.68		KMT2D_HUMAN (9-887): 1.59e-09: 64.6: 8.15
+	Hs
		818266 SOX2_HUMAN (736-852): 3.75e-28: 117: 15.39		KMT2C_HUMAN (278-935): 1.09e-10: 68.5: 8.60
+	Hs
		152690 SOX17_HUMAN (735-854): 4.58e-28: 119: 18.33		KMT2D_HUMAN (9-887): 1.59e-09: 64.6: 8.15
+	Hs
		643378 HMGB2_HUMAN (675-861): 3.05e-30: 120: 63.10		CBP_HUMAN (236-907): 8.37e-09: 61.9: 8.86
+	Hs
		152610 SOX2_HUMAN (736-852): 3.75e-28: 117: 15.39		KMT2D_HUMAN (9-887): 1.59e-09: 64.6: 8.15
+	Hs
		818263 SOX2_HUMAN (736-852): 3.75e-28: 117: 15.39		PHC3_HUMAN (180-907): 1.62e-09: 64.2: 7.91
+	Hs
		818230 SOX2_HUMAN (736-852): 3.75e-28: 117: 15.39		PHC2_HUMAN (22-663): 5.23e-09: 62.3: 11.37
+	Hs
		1270803 HM20A_HUMAN (708-877): 1.67e-26: 113: 20.00		CBP_HUMAN (236-907): 8.37e-09: 61.9: 8.86