HitPredict

Interactor 1: SP100 (P23497)
Nuclear autoantigen Sp-100 (Nuclear dot-associated Sp100 protein) (Speckled 100 kDa)
Gene: SP100

Interactor 2: V9HWG0 (V9HWG0)
Epididymis luminal protein 25
Gene: HEL25

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	25416956
Identification Methods	two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000781 - chromosome, telomeric region GO:0005654 - nucleoplasm GO:0005730 - nucleolus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 879 Hs			1 191
+	Hs
		617254 SP100_HUMAN (1-852): 0: 720: 100.00		CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00
+	Hs
		617293 SP100_HUMAN (1-852): 0: 720: 100.00		CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22
+	Hs
		617284 SP100_HUMAN (1-852): 0: 720: 100.00		CBX1_HUMAN (26-180): 2.32e-55: 175: 60.65
+	Hs
		800531 SP110_HUMAN (37-677): 1.52e-61: 223: 22.52		CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00
+	Hs
		1027272 SP110_HUMAN (37-677): 1.52e-61: 223: 22.52		CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22
+	Hs
		949890 SP110_HUMAN (37-677): 1.52e-61: 223: 22.52		CBX1_HUMAN (26-180): 2.32e-55: 175: 60.65
+	Hs
		449706 HMGB1_HUMAN (675-847): 9.29e-36: 136: 76.30		CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22
+	Hs
		175775 HMGB3_HUMAN (675-855): 1.68e-34: 132: 54.70		CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22
+	Mm
		818718 SOX2_MOUSE (762-852): 1.25e-27: 116: 19.78		CBX5_MOUSE (1-191): 1.9e-68: 208: 97.91
+	Hs
		996646 SSRP1_HUMAN (642-837): 4.16e-29: 126: 22.57		CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22
+	Hs
		643340 HMGB2_HUMAN (675-861): 3.05e-30: 120: 63.10		CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22
+	Mm
		818771 SOX2_MOUSE (762-852): 1.25e-27: 116: 19.78		Q9DCC5_MOUSE (1-181): 3.06e-62: 192: 60.22
+	Mm
		818693 SOX2_MOUSE (762-852): 1.25e-27: 116: 19.78		CBX1_MOUSE (26-180): 2.32e-55: 175: 60.65
+	Dm
		1363173 Q9VUD3_DROME (758-849): 3.27e-30: 128: 20.65		Q9VCU6_DROME (15-170): 2.56e-48: 159: 35.03
+	Dm
		114467 M9PCG2_DROME (758-849): 1.56e-29: 126: 20.65		Q9VCU6_DROME (15-170): 2.56e-48: 159: 35.03
+	Hs
		567688 UBF1_HUMAN (684-878): 1.22e-16: 86.7: 22.56		CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22
+	Hs
		996672 SSRP1_HUMAN (642-837): 4.16e-29: 126: 22.57		CBX2_HUMAN (10-111): 5.1e-24: 99.9: 31.37
+	Hs
		123201 SOX2_HUMAN (736-852): 3.75e-28: 117: 15.39		CBX4_HUMAN (11-125): 7.54e-26: 105: 25.22
+	Hs
		818053 SOX2_HUMAN (736-852): 3.75e-28: 117: 15.39		CBX2_HUMAN (10-111): 5.1e-24: 99.9: 31.37
+	Hs
		123152 TOX4_HUMAN (765-844): 1.52e-21: 101: 33.75		CBX4_HUMAN (11-125): 7.54e-26: 105: 25.22