HitPredict

Interactor 1: CDK1 (P23572)
Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase)
Gene: CDK1

Interactor 2: CCNC (P25008)
Cyclin-C
Gene: CycC

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	1.00	0.785

Property	Details
Experiments	15575970, 16603075
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Cyclin_C_2~Pkinase, Cyclin_N~Pkinase
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 297 Dm			1 267
+	Hs
		625350 CDK2_HUMAN (1-293): 7.76e-161: 450: 62.80		CCNA1_HUMAN (10-265): 6.46e-81: 252: 18.77
+	Hs
		538471 CDK2_HUMAN (1-293): 7.76e-161: 450: 62.80		CCNB1_HUMAN (1-266): 2.99e-79: 247: 15.19
+	Hs
		590125 CDK2_HUMAN (1-293): 7.76e-161: 450: 62.80		CCNA2_HUMAN (10-266): 1.76e-75: 237: 15.97
+	Hs
		303829 CDK2_HUMAN (1-293): 7.76e-161: 450: 62.80		CCNB2_HUMAN (1-266): 1.23e-73: 231: 15.93
+	Mm
		956329 CDK2_MOUSE (1-293): 8.94e-152: 430: 53.67		CCNA1_MOUSE (10-265): 4.58e-80: 249: 18.39
+	Hs
		538521 CDK3_HUMAN (1-289): 1.07e-151: 428: 65.40		CCNB1_HUMAN (1-266): 2.99e-79: 247: 15.19
+	Mm
		851183 CDK2_MOUSE (1-293): 8.94e-152: 430: 53.67		CCNA2_MOUSE (7-266): 3.28e-77: 241: 15.79
+	Hs
		414855 CDK1_HUMAN (1-292): 1.95e-146: 414: 72.95		CCNA1_HUMAN (10-265): 6.46e-81: 252: 18.77
+	Hs
		590162 CDK3_HUMAN (1-289): 1.07e-151: 428: 65.40		CCNA2_HUMAN (10-266): 1.76e-75: 237: 15.97
+	Hs
		414711 CDK1_HUMAN (1-292): 1.95e-146: 414: 72.95		CCNB1_HUMAN (1-266): 2.99e-79: 247: 15.19
+	Mm
		956332 CDK2_MOUSE (1-293): 8.94e-152: 430: 53.67		CCNC_MOUSE (1-258): 2.29e-73: 227: 71.71
+	Hs
		624422 CDK3_HUMAN (1-289): 1.07e-151: 428: 65.40		CCNC_HUMAN (1-258): 6.8e-73: 226: 71.71
+	Hs
		414732 CDK1_HUMAN (1-292): 1.95e-146: 414: 72.95		CCNA2_HUMAN (10-266): 1.76e-75: 237: 15.97
+	Xl
		526765 CDK1A_XENLA (1-295): 4.26e-147: 416: 69.83		CCNB1_XENLA (1-266): 2.67e-73: 230: 13.70
+	Hs
		303821 CDK1_HUMAN (1-292): 1.95e-146: 414: 72.95		CCNB2_HUMAN (1-266): 1.23e-73: 231: 15.93
+	Hs
		625251 CDK2_HUMAN (1-293): 7.76e-161: 450: 62.80		CCNH_HUMAN (5-260): 3.88e-59: 192: 22.49
+	Hs
		236679 CDK1_HUMAN (1-292): 1.95e-146: 414: 72.95		CCNT1_HUMAN (9-243): 7.66e-67: 222: 20.49
+	Hs
		960107 CDK3_HUMAN (1-289): 1.07e-151: 428: 65.40		CCNQ_HUMAN (33-246): 1.06e-61: 196: 23.48
+	Hs
		851197 CDK3_HUMAN (1-289): 1.07e-151: 428: 65.40		CCNH_HUMAN (5-260): 3.88e-59: 192: 22.49
+	Hs
		414989 CDK1_HUMAN (1-292): 1.95e-146: 414: 72.95		CCNQ_HUMAN (33-246): 1.06e-61: 196: 23.48