HitPredict

Interactor 1: CDK2 (P23573)
Cyclin-dependent kinase 2 (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 cognate)
Gene: CDK2

Interactor 2: Q9VHN1 (Q9VHN1)
Cyclin-dependent kinases regulatory subunit
Gene: Cks85A

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.775

Property	Details
Experiments	15575970, 21827746
Identification Methods	two hybrid, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	CKS~Pkinase
Common GO terms	GO:0000307 - cyclin-dependent protein kinase holoenzyme complex GO:0051301 - cell division
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 314 Dm			1 96
+	Hs
		625283 CDK2_HUMAN (5-293): 1.16e-155: 438: 64.73		CKS1_HUMAN (1-72): 3.79e-40: 129: 70.83
+	Dm
		618415 CDK1_DROME (5-291): 5.25e-136: 388: 59.11		Q9VHN1_DROME (1-96): 1.42e-58: 176: 100.00
+	Hs
		625164 CDK2_HUMAN (5-293): 1.16e-155: 438: 64.73		CKS2_HUMAN (1-72): 1.1e-38: 125: 68.06
+	Hs
		895413 CDK3_HUMAN (5-300): 3.85e-149: 422: 62.54		CKS1_HUMAN (1-72): 3.79e-40: 129: 70.83
+	Hs
		706796 CDK3_HUMAN (5-300): 3.85e-149: 422: 62.54		CKS2_HUMAN (1-72): 1.1e-38: 125: 68.06
+	Dm
		618437 CDK2_DROME (1-314): 2.57e-144: 410: 100.00		CKS1_DROME (3-73): 1.94e-39: 127: 64.79
+	Hs
		414843 CDK1_HUMAN (5-292): 7.45e-140: 398: 57.19		CKS1_HUMAN (1-72): 3.79e-40: 129: 70.83
+	Hs
		414778 CDK1_HUMAN (5-292): 7.45e-140: 398: 57.19		CKS2_HUMAN (1-72): 1.1e-38: 125: 68.06
+	Hs
		895414 CDK5_HUMAN (5-293): 4.41e-138: 393: 49.32		CKS1_HUMAN (1-72): 3.79e-40: 129: 70.83
+	At
		188136 CDKA1_ARATH (5-290): 7.77e-139: 395: 58.76		CKS1_ARATH (5-72): 6.8e-39: 126: 72.06
+	Hs
		706797 CDK5_HUMAN (5-293): 4.41e-138: 393: 49.32		CKS2_HUMAN (1-72): 1.1e-38: 125: 68.06
+	At
		621728 CDKA1_ARATH (5-290): 7.77e-139: 395: 58.76		CKS2_ARATH (5-72): 1.44e-37: 122: 67.65
+	Dm
		618387 CDK1_DROME (5-291): 5.25e-136: 388: 59.11		CKS1_DROME (3-73): 1.94e-39: 127: 64.79
+	Ce
		712291 CDK1_CAEEL (5-299): 2.49e-132: 380: 55.88		CKS1_CAEEL (3-72): 2.22e-40: 130: 61.43
+	At
		1321299 CDKD1_ARATH (2-309): 1.28e-133: 386: 41.10		CKS2_ARATH (5-72): 1.44e-37: 122: 67.65
+	At
		188168 CDKD3_ARATH (2-312): 4.88e-130: 377: 40.71		CKS1_ARATH (5-72): 6.8e-39: 126: 72.06
+	At
		188163 CDKD2_ARATH (5-305): 1.69e-130: 376: 42.38		CKS1_ARATH (5-72): 6.8e-39: 126: 72.06
+	At
		1338686 CDKD3_ARATH (2-312): 4.88e-130: 377: 40.71		CKS2_ARATH (5-72): 1.44e-37: 122: 67.65
+	At
		1321252 CDKD2_ARATH (5-305): 1.69e-130: 376: 42.38		CKS2_ARATH (5-72): 1.44e-37: 122: 67.65
+	Sp
		383445 CDK1_SCHPO (5-291): 2.84e-132: 379: 56.23		CKS1_SCHPO (4-73): 9.18e-35: 116: 46.84