HitPredict

Interactor 1: IF4B (P23588)
Eukaryotic translation initiation factor 4B (eIF-4B)
Gene: EIF4B

Interactor 2: IF4A1 (P60842)
Eukaryotic initiation factor 4A-I (eIF-4A-I) (eIF4A-I) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-1)
Gene: EIF4A1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	29395067
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0003743 - translation initiation factor activity GO:0005829 - cytosol GO:0016281 - eukaryotic translation initiation factor 4F complex
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 611 Hs			1 406
+	Hs
		618625 IF4B_HUMAN (1-611): 6.54e-98: 313: 100.00		IF4A2_HUMAN (4-406): 4.47e-158: 453: 90.32
+	Hs
		618544 IF4B_HUMAN (1-611): 6.54e-98: 313: 100.00		IF4A3_HUMAN (1-406): 1.93e-134: 393: 66.75
+	Sc
		485691 IF4B_YEAST (86-249): 9.35e-31: 126: 20.59		IF4A_YEAST (20-406): 8.01e-168: 477: 66.41
+	Mm
		496133 IF4H_MOUSE (83-245): 7.97e-39: 145: 33.13		IF4A2_MOUSE (4-406): 4.47e-158: 453: 90.32
+	Hs
		516515 PABP1_HUMAN (49-537): 3.4e-25: 112: 10.22		IF4A2_HUMAN (4-406): 4.47e-158: 453: 90.32
+	Hs
		1031325 PABP4_HUMAN (49-389): 1.92e-21: 100: 9.72		IF4A2_HUMAN (4-406): 4.47e-158: 453: 90.32
+	Mm
		892964 IF4H_MOUSE (83-245): 7.97e-39: 145: 33.13		IF4A1_MOUSE (1-406): 1.84e-132: 387: 100.00
+	Hs
		892812 IF4H_HUMAN (83-245): 1.61e-38: 144: 33.13		IF4A1_HUMAN (1-406): 1.84e-132: 387: 100.00
+	Hs
		516391 PABP1_HUMAN (49-537): 3.4e-25: 112: 10.22		IF4A3_HUMAN (1-406): 1.93e-134: 393: 66.75
+	Hs
		516434 PABP1_HUMAN (49-537): 3.4e-25: 112: 10.22		IF4A1_HUMAN (1-406): 1.84e-132: 387: 100.00
+	Hs
		892791 PABP4_HUMAN (49-389): 1.92e-21: 100: 9.72		IF4A1_HUMAN (1-406): 1.84e-132: 387: 100.00
+	Sc
		624037 NSR1_YEAST (84-187): 1.96e-10: 65.3: 20.00		DBP2_YEAST (2-404): 8.49e-137: 403: 31.63
+	Sc
		376792 PABP_YEAST (7-185): 1.17e-23: 107: 16.58		DHH1_YEAST (32-402): 1.41e-99: 307: 44.47
+	Hs
		516363 PABP1_HUMAN (49-537): 3.4e-25: 112: 10.22		DDX6_HUMAN (32-402): 1.66e-88: 278: 38.71
+	Hs
		640620 PABP3_HUMAN (54-547): 1.45e-22: 104: 11.07		DDX6_HUMAN (32-402): 1.66e-88: 278: 38.71
+	Hs
		640464 PABP4_HUMAN (49-389): 1.92e-21: 100: 9.72		DDX6_HUMAN (32-402): 1.66e-88: 278: 38.71