Interactor 1: IRF8 (P23611)
Interferon regulatory factor 8 (IRF-8) (Interferon consensus sequence-binding protein) (ICSBP)
Gene: IRF8

Interactor 2: IL12B (P43432)
Interleukin-12 subunit beta (IL-12B) (Cytotoxic lymphocyte maturation factor 40 kDa subunit) (CLMF p40) (IL-12 subunit p40)
Gene: IL12B

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.78 0.60 0.687

The method score is based on:

Property Details
Experiments 12876285, 19487420, 18055870, 12417340
Identification Methods electrophoretic mobility supershift assay, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005737 - cytoplasm
GO:0032729 - positive regulation of type II interferon production
GO:0032735 - positive regulation of interleukin-12 production
GO:0042832 - defense response to protozoan
GO:0071222 - cellular response to lipopolysaccharide
and 1 others

more...

Homologous interactions 8

Homologous interactions

Color coding for hit scores

1 424
Mm

1 335
+ Mm
+ Mm
+ Mm
+ Mm
+ Hs
+ Mm
+ Mm
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024