HitPredict

Interactor 1: AT2B4 (P23634)
Plasma membrane calcium-transporting ATPase 4 (PMCA4) (EC 7.2.2.10) (Matrix-remodeling-associated protein 1) (Plasma membrane calcium ATPase isoform 4) (Plasma membrane calcium pump isoform 4)
Gene: ATP2B4

Interactor 2: LPAR1 (Q92633)
Lysophosphatidic acid receptor 1 (LPA receptor 1) (LPA-1) (Lysophosphatidic acid receptor Edg-2)
Gene: LPAR1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	28514442
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0030165 - PDZ domain binding GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1241 Hs			1 364
+	Hs
		328308 AT2B4_HUMAN (1-1241): 0: 1300: 100.00		S1PR4_HUMAN (1-360): 9.27e-72: 230: 30.89
+	Hs
		208448 AT2B4_HUMAN (1-1241): 0: 1300: 100.00		OX2R_HUMAN (10-359): 1.2e-66: 218: 16.29
+	Hs
		428921 AT2B4_HUMAN (1-1241): 0: 1300: 100.00		ADRB2_HUMAN (54-350): 1.7e-66: 217: 17.38
+	Hs
		619198 AT2B4_HUMAN (1-1241): 0: 1300: 100.00		NK3R_HUMAN (13-364): 1.05e-63: 211: 15.85
+	Hs
		619204 AT2B4_HUMAN (1-1241): 0: 1300: 100.00		APJ_HUMAN (27-361): 1.19e-60: 201: 16.94
+	Hs
		619206 AT2B4_HUMAN (1-1241): 0: 1300: 100.00		OPRX_HUMAN (2-343): 2.72e-60: 200: 16.67
+	Hs
		328323 AT2B2_HUMAN (3-1241): 0: 1154: 68.59		S1PR4_HUMAN (1-360): 9.27e-72: 230: 30.89
+	Hs
		208456 AT2B3_HUMAN (1-1241): 0: 1164: 71.63		OX2R_HUMAN (10-359): 1.2e-66: 218: 16.29
+	Hs
		328307 AT2B1_HUMAN (1-1241): 0: 1148: 72.46		S1PR4_HUMAN (1-360): 9.27e-72: 230: 30.89
+	Hs
		664357 AT2B2_HUMAN (3-1241): 0: 1154: 68.59		AA2BR_HUMAN (45-327): 9.42e-70: 223: 23.45
+	Hs
		588547 AT2B1_HUMAN (1-1241): 0: 1148: 72.46		CNR2_HUMAN (46-349): 7.45e-71: 227: 24.52
+	Hs
		208453 AT2B2_HUMAN (3-1241): 0: 1154: 68.59		OX2R_HUMAN (10-359): 1.2e-66: 218: 16.29
+	Hs
		666307 AT2B2_HUMAN (3-1241): 0: 1154: 68.59		NK3R_HUMAN (13-364): 1.05e-63: 211: 15.85
+	Hs
		781059 AT2B3_HUMAN (1-1241): 0: 1164: 71.63		OPRX_HUMAN (2-343): 2.72e-60: 200: 16.67
+	Hs
		598738 AT2B3_HUMAN (1-1241): 0: 1164: 71.63		S1PR1_HUMAN (10-333): 3.19e-59: 197: 36.86
+	Hs
		781053 AT2B2_HUMAN (3-1241): 0: 1154: 68.59		OPRX_HUMAN (2-343): 2.72e-60: 200: 16.67
+	Hs
		598727 AT2B2_HUMAN (3-1241): 0: 1154: 68.59		S1PR1_HUMAN (10-333): 3.19e-59: 197: 36.86
+	Hs
		328306 AT1A3_HUMAN (27-1052): 0: 766: 24.34		S1PR4_HUMAN (1-360): 9.27e-72: 230: 30.89
+	Hs
		530839 AT1A3_HUMAN (27-1052): 0: 766: 24.34		NK3R_HUMAN (13-364): 1.05e-63: 211: 15.85
+	Hs
		530828 AT1A3_HUMAN (27-1052): 0: 766: 24.34		S1PR1_HUMAN (10-333): 3.19e-59: 197: 36.86