HitPredict

Interactor 1: PSA2 (P23639)
Proteasome subunit alpha type-2 (Macropain subunit Y7) (Multicatalytic endopeptidase complex subunit Y7) (Proteasome component Y7) (Proteinase YSCE subunit 7)
Gene: PRE8

Interactor 2: PSB3 (P25451)
Proteasome subunit beta type-3 (Macropain subunit PUP3) (Multicatalytic endopeptidase complex subunit PUP3) (Proteasome component PUP3)
Gene: PUP3

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.88	1.00	0.943

Property	Details
Experiments	11805826, 16554755, 16429126, 32868373, 37968396, 22940862
Identification Methods	tandem affinity purification, affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Proteasome~Proteasome, Proteasome~Proteasome_A_N
Common GO terms	GO:0000502 - proteasome complex GO:0005634 - nucleus GO:0010499 - proteasomal ubiquitin-independent protein catabolic process GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 250 Sc			1 205
+	Dm
		771285 PSA2_DROME (2-250): 2.44e-105: 306: 53.41		PSB1_DROME (4-205): 1.85e-76: 231: 30.37
+	Dm
		771294 PSA2_DROME (2-250): 2.44e-105: 306: 53.41		Q7K148_DROME (4-205): 1.88e-67: 209: 23.65
+	Dm
		771328 PSA2_DROME (2-250): 2.44e-105: 306: 53.41		PSB3_DROME (7-205): 6.25e-65: 200: 54.50
+	Dm
		771408 PSA5_DROME (3-250): 5e-93: 275: 30.59		PSB1_DROME (4-205): 1.85e-76: 231: 30.37
+	Dm
		771303 PSA2_DROME (2-250): 2.44e-105: 306: 53.41		PSA5_DROME (6-205): 7.81e-64: 199: 18.87
+	Sc
		619404 PSA2_YEAST (1-250): 4.68e-95: 280: 100.00		PSB6_YEAST (3-205): 1.03e-73: 224: 22.52
+	At
		286453 PSA6B_ARATH (5-250): 1.23e-106: 309: 30.52		PSB7B_ARATH (5-205): 1.88e-61: 194: 19.31
+	At
		188701 PSA6B_ARATH (5-250): 1.23e-106: 309: 30.52		PSB7A_ARATH (5-205): 2.79e-61: 193: 18.81
+	Dm
		771302 PSA2_DROME (2-250): 2.44e-105: 306: 53.41		Q8T8V8_DROME (7-196): 2.31e-61: 195: 19.90
+	Dm
		184454 PSA2_DROME (2-250): 2.44e-105: 306: 53.41		O17311_DROME (6-196): 1.82e-61: 194: 18.75
+	Mt
		191406 PSA_METTH (2-250): 3.69e-97: 285: 34.94		PSB_METTH (1-204): 2.77e-66: 204: 24.39
+	Dm
		1178944 PSA5_DROME (3-250): 5e-93: 275: 30.59		Q7K148_DROME (4-205): 1.88e-67: 209: 23.65
+	Af
		191426 PSA_ARCFU (4-248): 9.59e-95: 279: 36.33		PSB_ARCFU (6-205): 1.62e-66: 204: 26.37
+	Sc
		619422 PSA2_YEAST (1-250): 4.68e-95: 280: 100.00		PSB5_YEAST (4-195): 1.16e-64: 203: 22.80
+	Mm
		1154361 PSA_METMP (2-250): 4.61e-94: 278: 32.93		PSB_METMP (4-205): 8.31e-64: 198: 25.12
+	Dm
		1278656 PSA5_DROME (3-250): 5e-93: 275: 30.59		PSB3_DROME (7-205): 6.25e-65: 200: 54.50
+	Ph
		223381 PSA_PYRHO (3-248): 1.81e-98: 289: 39.02		PSB1_PYRHO (5-202): 1.33e-59: 186: 21.50
+	Hs
		594455 PSA5_HUMAN (3-250): 9.42e-92: 272: 30.04		PSB1_HUMAN (3-205): 9.86e-63: 196: 23.47
+	Dm
		47598 PSA2_DROME (2-250): 2.44e-105: 306: 53.41		A0AQH0_DROME (1-200): 1.38e-30: 113: 20.40
+	Dm
		47610 PSA5_DROME (3-250): 5e-93: 275: 30.59		A0AQH0_DROME (1-200): 1.38e-30: 113: 20.40