HitPredict

Interactor 1: PSA2 (P23639)
Proteasome subunit alpha type-2 (Macropain subunit Y7) (Multicatalytic endopeptidase complex subunit Y7) (Proteasome component Y7) (Proteinase YSCE subunit 7)
Gene: PRE8

Interactor 2: PSB5 (P30656)
Proteasome subunit beta type-5 (EC 3.4.25.1) (Macropain subunit PRE2) (Multicatalytic endopeptidase complex subunit PRE2) (Proteasome component PRE2) (Proteinase YSCE subunit PRE2)
Gene: PRE2

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	1.00	0.960

Property	Details
Experiments	17892321, 8628401, 15253422, 22940862, 14759368, 16554755, 32868373, 37968396
Identification Methods	anti tag coimmunoprecipitation, biochemical, affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Proteasome~Proteasome, Proteasome~Proteasome_A_N
Common GO terms	GO:0000502 - proteasome complex GO:0005634 - nucleus GO:0010499 - proteasomal ubiquitin-independent protein catabolic process GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 250 Sc			1 287
+	Dm
		771294 PSA2_DROME (2-250): 2.44e-105: 306: 53.41		Q7K148_DROME (8-280): 5.92e-83: 252: 46.93
+	Dm
		771303 PSA2_DROME (2-250): 2.44e-105: 306: 53.41		PSA5_DROME (50-276): 1.74e-83: 252: 16.94
+	Dm
		771329 PSA2_DROME (2-250): 2.44e-105: 306: 53.41		PSA6_DROME (44-279): 2.95e-81: 247: 17.07
+	Dm
		771302 PSA2_DROME (2-250): 2.44e-105: 306: 53.41		Q8T8V8_DROME (10-275): 1.42e-79: 245: 40.98
+	Dm
		184454 PSA2_DROME (2-250): 2.44e-105: 306: 53.41		O17311_DROME (47-284): 1.8e-79: 243: 24.59
+	Dm
		771324 PSA2_DROME (2-250): 2.44e-105: 306: 53.41		Q9VUJ1_DROME (40-284): 2e-75: 233: 24.60
+	At
		286453 PSA6B_ARATH (5-250): 1.23e-106: 309: 30.52		PSB7B_ARATH (39-266): 1.57e-73: 228: 24.35
+	At
		188701 PSA6B_ARATH (5-250): 1.23e-106: 309: 30.52		PSB7A_ARATH (39-266): 2.8e-73: 227: 24.78
+	Dm
		47598 PSA2_DROME (2-250): 2.44e-105: 306: 53.41		A0AQH0_DROME (71-262): 5.55e-75: 230: 27.08
+	Sc
		619428 PSA2_YEAST (1-250): 4.68e-95: 280: 100.00		PSA5_YEAST (50-281): 1.19e-81: 248: 17.96
+	Dm
		1178944 PSA5_DROME (3-250): 5e-93: 275: 30.59		Q7K148_DROME (8-280): 5.92e-83: 252: 46.93
+	Dm
		1278657 PSA5_DROME (3-250): 5e-93: 275: 30.59		PSA6_DROME (44-279): 2.95e-81: 247: 17.07
+	Sc
		619405 PSA2_YEAST (1-250): 4.68e-95: 280: 100.00		PSB2_YEAST (49-266): 1.52e-77: 237: 26.36
+	Sc
		619459 PSA2_YEAST (1-250): 4.68e-95: 280: 100.00		PSB1_YEAST (69-263): 3.22e-75: 230: 27.18
+	Dm
		1278650 PSA5_DROME (3-250): 5e-93: 275: 30.59		Q9VUJ1_DROME (40-284): 2e-75: 233: 24.60
+	Af
		191426 PSA_ARCFU (4-248): 9.59e-95: 279: 36.33		PSB_ARCFU (68-277): 1.24e-74: 228: 29.86
+	Mt
		191406 PSA_METTH (2-250): 3.69e-97: 285: 34.94		PSB_METTH (74-275): 2.31e-71: 220: 29.06
+	Dm
		47610 PSA5_DROME (3-250): 5e-93: 275: 30.59		A0AQH0_DROME (71-262): 5.55e-75: 230: 27.08
+	Mm
		1154361 PSA_METMP (2-250): 4.61e-94: 278: 32.93		PSB_METMP (71-278): 3.52e-72: 222: 26.79
+	Ph
		223381 PSA_PYRHO (3-248): 1.81e-98: 289: 39.02		PSB1_PYRHO (75-259): 1.14e-19: 86.3: 29.57