HitPredict

Interactor 1: PSA2 (P23639)
Proteasome subunit alpha type-2 (Macropain subunit Y7) (Multicatalytic endopeptidase complex subunit Y7) (Proteasome component Y7) (Proteinase YSCE subunit 7)
Gene: PRE8

Interactor 2: RPN1 (P38764)
26S proteasome regulatory subunit RPN1 (HMG-CoA reductase degradation protein 2) (Proteasome non-ATPase subunit 1)
Gene: RPN1

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	32868373, 19087962, 37968396
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000502 - proteasome complex GO:0005634 - nucleus GO:0034515 - proteasome storage granule GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 250 Sc			1 993
+	Hs
		656214 PSA5_HUMAN (3-250): 9.42e-92: 272: 30.04		PSMD2_HUMAN (2-989): 0: 1010: 34.61
+	Hs
		638122 PSA4_HUMAN (1-247): 4.63e-91: 270: 34.40		PSMD2_HUMAN (2-989): 0: 1010: 34.61
+	Hs
		893662 PSA6_HUMAN (2-250): 4.86e-91: 270: 32.54		PSMD2_HUMAN (2-989): 0: 1010: 34.61
+	Hs
		637679 PSA2_HUMAN (1-250): 3.12e-90: 267: 56.97		PSMD2_HUMAN (2-989): 0: 1010: 34.61
+	Sp
		293713 PSA2_SCHPO (1-250): 7.84e-92: 272: 66.00		RPN1_SCHPO (5-988): 0: 871: 37.71
+	Sp
		953217 PSA5_SCHPO (3-237): 5.78e-92: 272: 31.12		RPN1_SCHPO (5-988): 0: 871: 37.71
+	Sp
		953201 PSA3_SCHPO (1-220): 2.47e-91: 271: 33.33		RPN1_SCHPO (5-988): 0: 871: 37.71
+	Dm
		771325 PSA2_DROME (2-250): 2.44e-105: 306: 53.41		Q9VW54_DROME (1-989): 0: 738: 33.30
+	Dm
		1278652 PSA5_DROME (3-250): 5e-93: 275: 30.59		Q9VW54_DROME (1-989): 0: 738: 33.30
+	Hs
		656297 PSA5_HUMAN (3-250): 9.42e-92: 272: 30.04		PSMD1_HUMAN (52-925): 0: 709: 13.42
+	Hs
		638180 PSA4_HUMAN (1-247): 4.63e-91: 270: 34.40		PSMD1_HUMAN (52-925): 0: 709: 13.42
+	Hs
		893734 PSA6_HUMAN (2-250): 4.86e-91: 270: 32.54		PSMD1_HUMAN (52-925): 0: 709: 13.42
+	Hs
		637734 PSA2_HUMAN (1-250): 3.12e-90: 267: 56.97		PSMD1_HUMAN (52-925): 0: 709: 13.42
+	Dm
		771308 PSA2_DROME (2-250): 2.44e-105: 306: 53.41		PSMD1_DROME (52-925): 0: 664: 13.63
+	Dm
		1278636 PSA5_DROME (3-250): 5e-93: 275: 30.59		PSMD1_DROME (52-925): 0: 664: 13.63
+	Hs
		689 PSA5_HUMAN (3-250): 9.42e-92: 272: 30.04		A0A087WW66_HUMAN (52-925): 0: 645: 13.34
+	Hs
		688 PSA4_HUMAN (1-247): 4.63e-91: 270: 34.40		A0A087WW66_HUMAN (52-925): 0: 645: 13.34
+	Hs
		699 PSA6_HUMAN (2-250): 4.86e-91: 270: 32.54		A0A087WW66_HUMAN (52-925): 0: 645: 13.34
+	Hs
		686 PSA2_HUMAN (1-250): 3.12e-90: 267: 56.97		A0A087WW66_HUMAN (52-925): 0: 645: 13.34
+	Sc
		619434 PSA2_YEAST (1-250): 4.68e-95: 280: 100.00		RPN2_YEAST (52-815): 2.95e-177: 542: 15.54