HitPredict

Interactor 1: PSA2 (P23639)
Proteasome subunit alpha type-2 (Macropain subunit Y7) (Multicatalytic endopeptidase complex subunit Y7) (Proteasome component Y7) (Proteinase YSCE subunit 7)
Gene: PRE8

Interactor 2: RPN6 (Q12377)
26S proteasome regulatory subunit RPN6 (Proteasome non-ATPase subunit 4)
Gene: RPN6

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	1.00	0.834

Property	Details
Experiments	37968396, 32868373, 22237024
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Proteasome~RPN6_N
Common GO terms	GO:0000502 - proteasome complex GO:0034515 - proteasome storage granule GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 250 Sc			1 434
+	Dm
		771297 PSA2_DROME (2-250): 2.44e-105: 306: 53.41		PSD11_DROME (3-433): 1.12e-99: 306: 44.44
+	Dm
		1180708 PSA5_DROME (3-250): 5e-93: 275: 30.59		PSD11_DROME (3-433): 1.12e-99: 306: 44.44
+	Hs
		121689 PSA5_HUMAN (3-250): 9.42e-92: 272: 30.04		PSD11_HUMAN (1-433): 4.6e-98: 301: 41.01
+	Hs
		121685 PSA4_HUMAN (1-247): 4.63e-91: 270: 34.40		PSD11_HUMAN (1-433): 4.6e-98: 301: 41.01
+	Hs
		121719 PSA6_HUMAN (2-250): 4.86e-91: 270: 32.54		PSD11_HUMAN (1-433): 4.6e-98: 301: 41.01
+	Hs
		121635 PSA7_HUMAN (1-248): 8.69e-90: 267: 32.00		PSD11_HUMAN (1-433): 4.6e-98: 301: 41.01
+	Hs
		121684 PSA2_HUMAN (1-250): 3.12e-90: 267: 56.97		PSD11_HUMAN (1-433): 4.6e-98: 301: 41.01
+	Hs
		893638 PSA6_HUMAN (2-250): 4.86e-91: 270: 32.54		CSN2_HUMAN (7-431): 4.9e-93: 289: 19.95
+	Sp
		293717 PSA2_SCHPO (1-250): 7.84e-92: 272: 66.00		RPN6_SCHPO (6-431): 2.97e-89: 279: 48.12
+	Dm
		771305 PSA2_DROME (2-250): 2.44e-105: 306: 53.41		PSMD6_DROME (53-432): 3.17e-69: 226: 13.35
+	Hs
		656232 PSA5_HUMAN (3-250): 9.42e-92: 272: 30.04		PSMD6_HUMAN (65-432): 1.66e-73: 237: 13.78
+	Hs
		638133 PSA4_HUMAN (1-247): 4.63e-91: 270: 34.40		PSMD6_HUMAN (65-432): 1.66e-73: 237: 13.78
+	Hs
		893673 PSA6_HUMAN (2-250): 4.86e-91: 270: 32.54		PSMD6_HUMAN (65-432): 1.66e-73: 237: 13.78
+	Hs
		156291 PSA7_HUMAN (1-248): 8.69e-90: 267: 32.00		PSMD6_HUMAN (65-432): 1.66e-73: 237: 13.78
+	Hs
		637690 PSA2_HUMAN (1-250): 3.12e-90: 267: 56.97		PSMD6_HUMAN (65-432): 1.66e-73: 237: 13.78
+	Dm
		1278633 PSA5_DROME (3-250): 5e-93: 275: 30.59		PSMD6_DROME (53-432): 3.17e-69: 226: 13.35
+	Hs
		893660 PSA6_HUMAN (2-250): 4.86e-91: 270: 32.54		CSN1_HUMAN (41-433): 1.27e-68: 227: 12.07
+	Sc
		619400 PSA3_YEAST (4-214): 4.62e-42: 145: 37.09		RPN6_YEAST (1-434): 3.45e-95: 294: 100.00
+	Sp
		1013779 PSA4_SCHPO (5-214): 2.08e-41: 144: 38.39		RPN6_SCHPO (6-431): 2.97e-89: 279: 48.12
+	Dm
		771304 PSA2_DROME (2-250): 2.44e-105: 306: 53.41		CSN4_DROME (137-426): 9.88e-19: 89.5: 15.56