HitPredict - High confidence protein-protein interactions

Interactor 1: NUCL (P19338)
Nucleolin (Protein C23)
Gene: NCL

Interactor 2: NUCL (P19338)
Nucleolin (Protein C23)
Gene: NCL

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.847

Property	Details
Experiments	25313645, 25253489, 21575138
Identification Methods	affinity chromatography technology, cross-linking study, blue native page, surface plasmon resonance
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0001525 - angiogenesis GO:0001533 - cornified envelope GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm and 22 others more... GO:0005681 - spliceosomal complex GO:0005694 - chromosome GO:0005730 - nucleolus GO:0005886 - plasma membrane GO:0005938 - cell cortex GO:0016020 - membrane GO:0017148 - negative regulation of translation GO:0036464 - cytoplasmic ribonucleoprotein granule GO:0042162 - telomeric DNA binding GO:0042731 - PH domain binding GO:0043560 - insulin receptor substrate binding GO:0044547 - DNA topoisomerase binding GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0046627 - negative regulation of insulin receptor signaling pathway GO:0048026 - positive regulation of mRNA splicing, via spliceosome GO:0048027 - mRNA 5'-UTR binding GO:0070062 - extracellular exosome GO:0071364 - cellular response to epidermal growth factor stimulus GO:0160056 - macropinosome membrane GO:1901838 - positive regulation of transcription of nucleolar large rRNA by RNA polymerase I GO:1990830 - cellular response to leukemia inhibitory factor GO:1990904 - ribonucleoprotein complex
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1	710
Hs

1	710

Service provided by Combinatics, Japan

Last updated: 11Aug2025