HitPredict

Interactor 1: VAMP1 (P23763)
Vesicle-associated membrane protein 1 (VAMP-1) (Synaptobrevin-1)
Gene: VAMP1

Interactor 2: STX1A (Q16623)
Syntaxin-1A (Neuron-specific antigen HPC-1)
Gene: STX1A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.845

Property	Details
Experiments	32296183, 12093152, unassigned1304
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	SNARE~Synaptobrevin, Synaptobrevin~Syntaxin
Common GO terms	GO:0005484 - SNAP receptor activity GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0030672 - synaptic vesicle membrane GO:0031201 - SNARE complex and 1 others more... GO:0043005 - neuron projection
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 118 Hs			1 288
+	Rn
		699183 VAMP7_RAT (2-99): 7.46e-34: 118: 27.55		STX1A_RAT (1-288): 3.03e-86: 261: 98.61
+	Dm
		1098086 Q7JYX5_DROME (3-113): 4.37e-38: 129: 24.32		STX1A_DROME (2-287): 2.6e-75: 233: 69.90
+	Dm
		577220 SYB_DROME (4-117): 1.61e-35: 120: 50.88		STX1A_DROME (2-287): 2.6e-75: 233: 69.90
+	At
		812702 VA722_ARATH (2-98): 3.18e-42: 139: 26.53		SY121_ARATH (19-266): 2.64e-58: 191: 22.27
+	At
		1378372 VA721_ARATH (2-98): 1.02e-41: 138: 26.53		SY121_ARATH (19-266): 2.64e-58: 191: 22.27
+	At
		1352937 VA721_ARATH (2-98): 1.02e-41: 138: 26.53		SY122_ARATH (25-266): 1.04e-53: 179: 23.20
+	At
		1258650 VA721_ARATH (2-98): 1.02e-41: 138: 26.53		SY132_ARATH (13-266): 1.33e-52: 175: 23.49
+	At
		249598 VA721_ARATH (2-98): 1.02e-41: 138: 26.53		SYP41_ARATH (29-287): 3.69e-52: 175: 20.76
+	At
		1352876 VA721_ARATH (2-98): 1.02e-41: 138: 26.53		SYP43_ARATH (10-287): 2.85e-51: 172: 18.31
+	At
		1352985 VA721_ARATH (2-98): 1.02e-41: 138: 26.53		SYP42_ARATH (30-287): 2.78e-51: 172: 21.59
+	At
		812689 VA722_ARATH (2-98): 3.18e-42: 139: 26.53		SY111_ARATH (2-266): 6.77e-51: 171: 22.88
+	At
		1114744 VA721_ARATH (2-98): 1.02e-41: 138: 26.53		SY111_ARATH (2-266): 6.77e-51: 171: 22.88
+	Dm
		1097995 Q7JYX5_DROME (3-113): 4.37e-38: 129: 24.32		STX5_DROME (2-268): 2.15e-51: 176: 16.61
+	At
		955702 VA721_ARATH (2-98): 1.02e-41: 138: 26.53		SYP22_ARATH (14-272): 1.29e-48: 164: 18.89
+	Dm
		1178106 Q7JYX5_DROME (3-113): 4.37e-38: 129: 24.32		STX4_DROME (27-267): 6.23e-51: 172: 24.48
+	At
		955681 VA713_ARATH (3-115): 7.19e-41: 136: 23.01		SYP22_ARATH (14-272): 1.29e-48: 164: 18.89
+	At
		955679 VA714_ARATH (1-116): 4.6e-40: 134: 20.69		SYP22_ARATH (14-272): 1.29e-48: 164: 18.89
+	Dm
		577219 SYB_DROME (4-117): 1.61e-35: 120: 50.88		STX5_DROME (2-268): 2.15e-51: 176: 16.61
+	Dm
		577227 SYB_DROME (4-117): 1.61e-35: 120: 50.88		STX4_DROME (27-267): 6.23e-51: 172: 24.48
+	At
		221561 VA711_ARATH (3-116): 1.89e-36: 125: 22.81		SYP22_ARATH (14-272): 1.29e-48: 164: 18.89