HitPredict

Interactor 1: GATA2 (P23769)
Endothelial transcription factor GATA-2 (GATA-binding protein 2)
Gene: GATA2

Interactor 2: BMI1 (P35226)
Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4) (RING finger protein 51)
Gene: BMI1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	24457600
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0008270 - zinc ion binding
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 480 Hs			1 326
+	Hs
		620457 GATA3_HUMAN (1-480): 3.1e-135: 399: 61.24		BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00
+	Hs
		620415 GATA2_HUMAN (1-480): 0: 529: 100.00		PCGF1_HUMAN (2-229): 5.96e-62: 199: 36.33
+	Hs
		620374 GATA2_HUMAN (1-480): 0: 529: 100.00		PCGF5_HUMAN (1-228): 9.27e-56: 183: 30.44
+	Hs
		620412 GATA2_HUMAN (1-480): 0: 529: 100.00		RING2_HUMAN (7-227): 8.37e-50: 170: 16.61
+	Mm
		639472 GATA6_MOUSE (108-429): 3.06e-74: 246: 38.86		BMI1_MOUSE (1-326): 2.15e-150: 426: 96.93
+	Hs
		717527 GATA4_HUMAN (107-479): 1.15e-69: 230: 32.41		BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00
+	Mm
		639469 GATA4_MOUSE (107-479): 4.01e-68: 226: 32.83		BMI1_MOUSE (1-326): 2.15e-150: 426: 96.93
+	Hs
		620334 GATA2_HUMAN (1-480): 0: 529: 100.00		RING1_HUMAN (7-115): 2.38e-30: 120: 25.46
+	Hs
		718284 TRPS1_HUMAN (153-447): 1.96e-56: 204: 23.76		BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00
+	Hs
		620564 GATA3_HUMAN (1-480): 3.1e-135: 399: 61.24		PCGF1_HUMAN (2-229): 5.96e-62: 199: 36.33
+	Hs
		620562 GATA3_HUMAN (1-480): 3.1e-135: 399: 61.24		RING2_HUMAN (7-227): 8.37e-50: 170: 16.61
+	Hs
		620485 GATA3_HUMAN (1-480): 3.1e-135: 399: 61.24		RING1_HUMAN (7-115): 2.38e-30: 120: 25.46
+	Hs
		554507 GATA1_HUMAN (186-480): 8.32e-69: 227: 43.35		PCGF1_HUMAN (2-229): 5.96e-62: 199: 36.33
+	Hs
		798986 GATA4_HUMAN (107-479): 1.15e-69: 230: 32.41		RING2_HUMAN (7-227): 8.37e-50: 170: 16.61
+	Mm
		994733 GATA4_MOUSE (107-479): 4.01e-68: 226: 32.83		RING2_MOUSE (7-227): 5.77e-50: 171: 16.61
+	Hs
		554435 GATA1_HUMAN (186-480): 8.32e-69: 227: 43.35		RING1_HUMAN (7-115): 2.38e-30: 120: 25.46