HitPredict

Interactor 1: GATA3 (P23771)
Trans-acting T-cell-specific transcription factor GATA-3 (GATA-binding factor 3)
Gene: GATA3

Interactor 2: RING1 (Q06587)
E3 ubiquitin-protein ligase RING1 (EC 2.3.2.27) (Polycomb complex protein RING1) (RING finger protein 1) (RING-type E3 ubiquitin transferase RING1) (Really interesting new gene 1 protein)
Gene: RING1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35140242
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006338 - chromatin remodeling GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 443 Hs			1 406
+	Hs
		620562 GATA3_HUMAN (1-443): 2.52e-176: 502: 100.00		RING2_HUMAN (8-406): 4.9e-100: 302: 54.25
+	Hs
		620334 GATA2_HUMAN (1-443): 3.16e-135: 399: 61.24		RING1_HUMAN (1-406): 2.01e-114: 342: 100.00
+	Hs
		620457 GATA3_HUMAN (1-443): 2.52e-176: 502: 100.00		BMI1_HUMAN (31-378): 4.06e-63: 207: 14.16
+	Hs
		620412 GATA2_HUMAN (1-443): 3.16e-135: 399: 61.24		RING2_HUMAN (8-406): 4.9e-100: 302: 54.25
+	Hs
		620564 GATA3_HUMAN (1-443): 2.52e-176: 502: 100.00		PCGF1_HUMAN (25-133): 3.54e-40: 145: 25.00
+	Hs
		620460 GATA3_HUMAN (1-443): 2.52e-176: 502: 100.00		BRCA1_HUMAN (33-361): 4.24e-35: 139: 15.63
+	Hs
		620304 GATA2_HUMAN (1-443): 3.16e-135: 399: 61.24		BMI1_HUMAN (31-378): 4.06e-63: 207: 14.16
+	Hs
		620388 GATA2_HUMAN (1-443): 3.16e-135: 399: 61.24		COP1_HUMAN (40-326): 3.5e-39: 151: 18.31
+	Hs
		554435 GATA1_HUMAN (186-443): 1.66e-60: 204: 40.56		RING1_HUMAN (1-406): 2.01e-114: 342: 100.00
+	Hs
		620415 GATA2_HUMAN (1-443): 3.16e-135: 399: 61.24		PCGF1_HUMAN (25-133): 3.54e-40: 145: 25.00
+	Hs
		620374 GATA2_HUMAN (1-443): 3.16e-135: 399: 61.24		PCGF5_HUMAN (31-147): 4.96e-38: 139: 23.33
+	Hs
		798986 GATA4_HUMAN (134-436): 2.12e-72: 236: 38.87		RING2_HUMAN (8-406): 4.9e-100: 302: 54.25
+	Mm
		994733 GATA4_MOUSE (136-436): 4.71e-69: 227: 39.19		RING2_MOUSE (8-406): 2.94e-100: 303: 54.25
+	Mm
		639472 GATA6_MOUSE (92-430): 5.07e-82: 265: 33.71		BMI1_MOUSE (31-378): 1.44e-62: 206: 14.16
+	Hs
		718284 TRPS1_HUMAN (139-433): 2.17e-73: 252: 24.10		BMI1_HUMAN (31-378): 4.06e-63: 207: 14.16
+	Hs
		717527 GATA4_HUMAN (134-436): 2.12e-72: 236: 38.87		BMI1_HUMAN (31-378): 4.06e-63: 207: 14.16
+	Mm
		639469 GATA4_MOUSE (136-436): 4.71e-69: 227: 39.19		BMI1_MOUSE (31-378): 1.44e-62: 206: 14.16
+	Hs
		554507 GATA1_HUMAN (186-443): 1.66e-60: 204: 40.56		PCGF1_HUMAN (25-133): 3.54e-40: 145: 25.00