HitPredict

Interactor 1: PCGF2 (P23798)
Polycomb group RING finger protein 2 (DNA-binding protein Mel-18) (Melanoma nuclear protein 18) (RING finger protein 110) (Zinc finger protein 144) (Zfp-144)
Gene: PCGF2

Interactor 2: CBX7 (Q8VDS3)
Chromobox protein homolog 7
Gene: CBX7

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.51	1.00	0.715

Property	Details
Experiments	22325148
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	CBX7_C~RAWUL
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0006325 - chromatin organization GO:0031519 - PcG protein complex and 1 others more... GO:0035102 - PRC1 complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 342 Mm			1 158
+	Hs
		123194 PCGF2_HUMAN (1-342): 4.23e-95: 288: 95.91		CBX4_HUMAN (1-126): 3e-32: 121: 46.03
+	Hs
		315977 PCGF2_HUMAN (1-342): 4.23e-95: 288: 95.91		CBX6_HUMAN (1-125): 2.05e-30: 115: 39.86
+	Hs
		718431 PCGF2_HUMAN (1-342): 4.23e-95: 288: 95.91		CBX8_HUMAN (1-81): 2.86e-29: 111: 64.20
+	Mm
		223225 PCGF2_MOUSE (1-342): 5.75e-89: 272: 100.00		CBX4_MOUSE (1-126): 2.02e-32: 122: 46.83
+	Hs
		718398 PCGF2_HUMAN (1-342): 4.23e-95: 288: 95.91		CBX2_HUMAN (2-100): 8.27e-26: 103: 41.41
+	Mm
		620795 PCGF2_MOUSE (1-342): 5.75e-89: 272: 100.00		CBX8_MOUSE (1-123): 3.89e-30: 113: 44.93
+	Hs
		718395 PCGF2_HUMAN (1-342): 4.23e-95: 288: 95.91		CBX3_HUMAN (9-154): 2.17e-23: 92.2: 22.45
+	Mm
		620782 PCGF2_MOUSE (1-342): 5.75e-89: 272: 100.00		CBX2_MOUSE (2-100): 2.6e-26: 104: 41.41
+	Hs
		123193 BMI1_HUMAN (1-341): 8.37e-81: 250: 61.40		CBX4_HUMAN (1-126): 3e-32: 121: 46.03
+	Hs
		315976 BMI1_HUMAN (1-341): 8.37e-81: 250: 61.40		CBX6_HUMAN (1-125): 2.05e-30: 115: 39.86
+	Hs
		718213 BMI1_HUMAN (1-341): 8.37e-81: 250: 61.40		CBX8_HUMAN (1-81): 2.86e-29: 111: 64.20
+	Mm
		639481 BMI1_MOUSE (1-341): 1.86e-78: 244: 61.11		CBX8_MOUSE (1-123): 3.89e-30: 113: 44.93
+	Dr
		1193374 BMI1A_DANRE (1-341): 7.61e-75: 235: 60.70		Q804D1_DANRE (1-110): 1.76e-32: 121: 52.73
+	Hs
		717831 BMI1_HUMAN (1-341): 8.37e-81: 250: 61.40		CBX2_HUMAN (2-100): 8.27e-26: 103: 41.41
+	Hs
		327831 PCGF2_HUMAN (1-342): 4.23e-95: 288: 95.91		CBX7_HUMAN (48-158): 1.39e-12: 64.9: 57.52
+	Mm
		639466 BMI1_MOUSE (1-341): 1.86e-78: 244: 61.11		CBX2_MOUSE (2-100): 2.6e-26: 104: 41.41
+	Hs
		718131 BMI1_HUMAN (1-341): 8.37e-81: 250: 61.40		MPP8_HUMAN (2-143): 1.92e-23: 97.2: 21.68
+	Hs
		717529 BMI1_HUMAN (1-341): 8.37e-81: 250: 61.40		CBX5_HUMAN (11-119): 3.88e-25: 96.9: 23.85
+	Hs
		717776 BMI1_HUMAN (1-341): 8.37e-81: 250: 61.40		CBX3_HUMAN (9-154): 2.17e-23: 92.2: 22.45
+	Hs
		327830 BMI1_HUMAN (1-341): 8.37e-81: 250: 61.40		CBX7_HUMAN (48-158): 1.39e-12: 64.9: 57.52