Interactor 1: MDM2 (P23804)
E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2)
Gene: MDM2

Interactor 2: MDM2 (P23804)
E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2)
Gene: MDM2

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.60 1.00 0.778

The method score is based on:

Property Details
Experiments 18566590, 17086174
Identification Methods enzymatic study
Interaction Type direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains SWIB~SWIB, zf-C3HC4_3~zf-C3HC4_3
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0001568 - blood vessel development
GO:0001974 - blood vessel remodeling
GO:0002027 - regulation of heart rate
GO:0002039 - p53 binding
and 71 others

more...

Homologous interactions 5

Homologous interactions

Color coding for hit scores

1 489
Mm

1 489
+ Hs
+ Mm
+ Hs
+ Hs
+ Dr

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Last updated: 15 Jul 2024