HitPredict

Interactor 1: MDM2 (P23804)
E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2)
Gene: MDM2

Interactor 2: 1433T (P68254)
14-3-3 protein theta (14-3-3 protein tau)
Gene: Ywhaq

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	20086099
Identification Methods	pull down
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 489 Mm			1 245
+	Hs
		646805 MDM2_HUMAN (1-488): 0: 636: 80.85		1433T_HUMAN (1-245): 7.86e-142: 398: 99.59
+	Hs
		926930 MDM2_HUMAN (1-488): 0: 636: 80.85		1433Z_HUMAN (1-245): 1.19e-141: 398: 79.18
+	Hs
		169269 MDM4_HUMAN (4-488): 0: 560: 31.61		1433E_HUMAN (2-243): 9.76e-145: 406: 63.93
+	Hs
		169241 MDM4_HUMAN (4-488): 0: 560: 31.61		1433T_HUMAN (1-245): 7.86e-142: 398: 99.59
+	Hs
		169273 MDM4_HUMAN (4-488): 0: 560: 31.61		1433Z_HUMAN (1-245): 1.19e-141: 398: 79.18
+	Hs
		169244 MDM4_HUMAN (4-488): 0: 560: 31.61		1433B_HUMAN (1-242): 4.03e-139: 391: 81.82
+	Hs
		683969 MDM2_HUMAN (1-488): 0: 636: 80.85		1433S_HUMAN (1-236): 7.54e-107: 310: 71.43
+	Mm
		193158 MDM4_MOUSE (4-488): 0: 571: 31.69		1433G_MOUSE (1-242): 2.97e-105: 306: 70.73
+	Hs
		169245 MDM4_HUMAN (4-488): 0: 560: 31.61		1433S_HUMAN (1-236): 7.54e-107: 310: 71.43
+	Hs
		169280 MDM4_HUMAN (4-488): 0: 560: 31.61		1433F_HUMAN (2-242): 4.99e-106: 308: 71.84
+	Hs
		169266 MDM4_HUMAN (4-488): 0: 560: 31.61		1433G_HUMAN (1-242): 2.97e-105: 306: 70.73