HitPredict

Interactor 1: MDM2 (P23804)
E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2)
Gene: MDM2

Interactor 2: UBP7 (Q6A4J8)
Ubiquitin carboxyl-terminal hydrolase 7 (EC 3.4.19.12) (Deubiquitinating enzyme 7) (Herpesvirus-associated ubiquitin-specific protease) (mHAUSP) (Ubiquitin thioesterase 7) (Ubiquitin-specific-processing protease 7)
Gene: Usp7

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	20697359, 18566590
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 489 Mm			1 1103
+	Hs
		962904 MDM2_HUMAN (1-488): 0: 636: 80.85		UBP7_HUMAN (1-1103): 0: 1221: 98.91
+	Mm
		193159 MDM4_MOUSE (4-488): 0: 571: 31.69		UBP7_MOUSE (1-1103): 0: 1225: 100.00
+	Hs
		169299 MDM4_HUMAN (4-488): 0: 560: 31.61		UBP7_HUMAN (1-1103): 0: 1221: 98.91
+	Hs
		962847 MDM2_HUMAN (1-488): 0: 636: 80.85		UBP48_HUMAN (207-573): 1.5e-100: 343: 26.90
+	Hs
		962832 MDM2_HUMAN (1-488): 0: 636: 80.85		UBP51_HUMAN (61-526): 1.2e-98: 330: 16.46
+	Hs
		962979 MDM2_HUMAN (1-488): 0: 636: 80.85		UBP42_HUMAN (185-556): 1.25e-88: 314: 21.85
+	Hs
		259276 MDM2_HUMAN (1-488): 0: 636: 80.85		UBP12_HUMAN (190-523): 6.42e-90: 295: 25.55
+	Hs
		169314 MDM4_HUMAN (4-488): 0: 560: 31.61		UBP22_HUMAN (45-522): 3.3e-108: 350: 15.94