HitPredict

Interactor 1: RIR1 (P23921)
Ribonucleoside-diphosphate reductase large subunit (EC 1.17.4.1) (Ribonucleoside-diphosphate reductase subunit M1) (Ribonucleotide reductase large subunit)
Gene: RRM1

Interactor 2: RIR1 (P23921)
Ribonucleoside-diphosphate reductase large subunit (EC 1.17.4.1) (Ribonucleoside-diphosphate reductase subunit M1) (Ribonucleotide reductase large subunit)
Gene: RRM1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.82 1.00 0.908

The method score is based on:

Property Details
Experiments 25416956, 11781084, 17726094, 21336276
Identification Methods two hybrid, pull down, two hybrid array, molecular sieving, x-ray crystallography, light scattering
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains ATP-cone~ATP-cone, ATP-cone~Ribonuc_red_lgC, ATP-cone~Ribonuc_red_lgN, Ribonuc_red_lgC~Ribonuc_red_lgC, Ribonuc_red_lgC~Ribonuc_red_lgN
Common GO terms GO:0000731 - DNA synthesis involved in DNA repair
GO:0004748 - ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0005524 - ATP binding
GO:0005635 - nuclear envelope
GO:0005739 - mitochondrion
and 20 others

more...
Homologous interactions 9

Homologous interactions

Color coding for hit scores

1 792
Hs

1 792
+ Sc
+ Sc
+ Vv
+ Ec
+ Hh
+ Ha
+ Ha
+ Hh
+ Mb

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024