Interactor 1: RIR1 (P23921)
Ribonucleoside-diphosphate reductase large subunit (EC 1.17.4.1) (Ribonucleoside-diphosphate reductase subunit M1) (Ribonucleotide reductase large subunit)
Gene: RRM1
Interactor 2: RIR2 (P31350)
Ribonucleoside-diphosphate reductase subunit M2 (EC 1.17.4.1) (Ribonucleotide reductase small chain) (Ribonucleotide reductase small subunit)
Gene: RRM2
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.95 | 1.00 | 0.976 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 28514442, 14583450, 26264872, 11781084, 33961781, 20159953, 22632967, 12615712, 17726094, 21336276 |
| Identification Methods | affinity chromatography technology, pull down, two hybrid, coimmunoprecipitation, molecular sieving, anti tag coimmunoprecipitation |
| Interaction Type | physical association, direct interaction, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | ATP-cone~Ribonuc_red_sm, Ribonuc_red_lgC~Ribonuc_red_sm |
| Common GO terms | GO:0004748 - ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor GO:0005829 - cytosol GO:0005971 - ribonucleoside-diphosphate reductase complex GO:0009185 - ribonucleoside diphosphate metabolic process GO:0009263 - deoxyribonucleotide biosynthetic process and 3 others more... |
| Homologous interactions | 13 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
