Interactor 1: RIR1 (P23921)
Ribonucleoside-diphosphate reductase large subunit (EC 1.17.4.1) (Ribonucleoside-diphosphate reductase subunit M1) (Ribonucleotide reductase large subunit)
Gene: RRM1

Interactor 2: RIR2B (Q7LG56)
Ribonucleoside-diphosphate reductase subunit M2 B (EC 1.17.4.1) (TP53-inducible ribonucleotide reductase M2 B) (p53-inducible ribonucleotide reductase small subunit 2-like protein) (p53R2)
Gene: RRM2B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.80 1.00 0.897

The method score is based on:

Property Details
Experiments 28514442, 14583450, 33961781, 20159953
Identification Methods affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains ATP-cone~Ribonuc_red_sm, Ribonuc_red_lgC~Ribonuc_red_sm
Common GO terms GO:0000731 - DNA synthesis involved in DNA repair
GO:0004748 - ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0005739 - mitochondrion
GO:0005829 - cytosol
GO:0005971 - ribonucleoside-diphosphate reductase complex
and 7 others

more...

Homologous interactions 13

Homologous interactions

Color coding for hit scores

1 792
Hs

1 351
+ Mm
+ Hs
+ Sp
+ Sc
+ Vv
+ Sc
+ Sc
+ Ec
+ Hh
+ Ha
+ Hh
+ Hh
+ Mp

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024