HitPredict

Interactor 1: CDKA1 (P24100)
Cyclin-dependent kinase A-1 (CDKA;1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog A) (CDC2aAt)
Gene: CDKA-1

Interactor 2: CCD11 (P42751)
Cyclin-D1-1 (Cyclin-delta-1) (Cyclin-d1) (G1/S-specific cyclin-D1-1) (CycD1;1)
Gene: CYCD1-1

Species: Arabidopsis thaliana

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.61	1.00	0.781

Property	Details
Experiments	12857813, 20407024
Identification Methods	pull down, protein complementation assay
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Cyclin_C~Pkinase, Cyclin_N~Pkinase
Common GO terms	GO:0000307 - cyclin-dependent protein kinase holoenzyme complex GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 294 At			1 339
+	Hs
		625350 CDK2_HUMAN (1-293): 6.46e-149: 420: 67.92		CCNA1_HUMAN (10-315): 3e-94: 289: 21.82
+	Hs
		538471 CDK2_HUMAN (1-293): 6.46e-149: 420: 67.92		CCNB1_HUMAN (10-316): 2.01e-90: 278: 19.17
+	Hs
		538521 CDK3_HUMAN (1-294): 1.39e-146: 415: 68.03		CCNB1_HUMAN (10-316): 2.01e-90: 278: 19.17
+	Hs
		590125 CDK2_HUMAN (1-293): 6.46e-149: 420: 67.92		CCNA2_HUMAN (20-312): 8.2e-88: 272: 23.55
+	At
		621662 CDKA1_ARATH (1-294): 6.8e-145: 410: 100.00		CCA21_ARATH (1-318): 1.22e-90: 279: 19.44
+	Hs
		590162 CDK3_HUMAN (1-294): 1.39e-146: 415: 68.03		CCNA2_HUMAN (20-312): 8.2e-88: 272: 23.55
+	Hs
		303829 CDK2_HUMAN (1-293): 6.46e-149: 420: 67.92		CCNB2_HUMAN (1-320): 1.73e-84: 262: 17.99
+	At
		621661 CDKA1_ARATH (1-294): 6.8e-145: 410: 100.00		CCB12_ARATH (14-326): 1.34e-87: 271: 21.00
+	At
		621653 CDKA1_ARATH (1-294): 6.8e-145: 410: 100.00		CCA22_ARATH (1-318): 6.35e-87: 270: 19.63
+	At
		621660 CDKA1_ARATH (1-294): 6.8e-145: 410: 100.00		CCA23_ARATH (5-309): 2.59e-85: 266: 17.65
+	At
		48929 CDKA1_ARATH (1-294): 6.8e-145: 410: 100.00		CCA33_ARATH (38-316): 3.78e-85: 261: 18.79
+	At
		621647 CDKA1_ARATH (1-294): 6.8e-145: 410: 100.00		CCD21_ARATH (16-322): 3.19e-84: 260: 37.70
+	At
		621643 CDKA1_ARATH (1-294): 6.8e-145: 410: 100.00		CCB11_ARATH (18-309): 3.44e-81: 254: 21.97
+	Hs
		625156 CDK2_HUMAN (1-293): 6.46e-149: 420: 67.92		CCND3_HUMAN (51-318): 4.12e-75: 235: 23.42
+	Hs
		673140 CDK3_HUMAN (1-294): 1.39e-146: 415: 68.03		CCND3_HUMAN (51-318): 4.12e-75: 235: 23.42
+	Rn
		981205 Q6P751_RAT (1-293): 1.25e-148: 420: 67.92		CCND2_RAT (32-325): 2.04e-71: 225: 20.88
+	Hs
		625155 CDK2_HUMAN (1-293): 6.46e-149: 420: 67.92		CCND2_HUMAN (55-325): 3.33e-71: 224: 21.90
+	At
		621652 CDKA1_ARATH (1-294): 6.8e-145: 410: 100.00		CCD42_ARATH (18-243): 6.6e-73: 229: 40.09
+	At
		621648 CDKA1_ARATH (1-294): 6.8e-145: 410: 100.00		CCD31_ARATH (79-283): 6.07e-71: 226: 37.07
+	At
		621658 CDKA1_ARATH (1-294): 6.8e-145: 410: 100.00		CCD51_ARATH (8-324): 1.66e-64: 208: 26.61