HitPredict

Interactor 1: CDKA1 (P24100)
Cyclin-dependent kinase A-1 (CDKA;1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog A) (CDC2aAt)
Gene: CDKA-1

Interactor 2: CCD51 (Q2V3B2)
Cyclin-D5-1 (G1/S-specific cyclin-D5-1) (CycD5;1)
Gene: CYCD5-1

Species: Arabidopsis thaliana

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.63	1.00	0.794

Property	Details
Experiments	20407024, 20706207
Identification Methods	protein complementation assay, two hybrid, affinity chromatography technology, tandem affinity purification
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Cyclin_N~Pkinase
Common GO terms	GO:0000307 - cyclin-dependent protein kinase holoenzyme complex GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0042023 - DNA endoreduplication
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 294 At			1 323
+	Hs
		538471 CDK2_HUMAN (1-293): 6.46e-149: 420: 67.92		CCNB1_HUMAN (6-305): 2.97e-84: 262: 14.33
+	Hs
		538521 CDK3_HUMAN (1-294): 1.39e-146: 415: 68.03		CCNB1_HUMAN (6-305): 2.97e-84: 262: 14.33
+	Hs
		303829 CDK2_HUMAN (1-293): 6.46e-149: 420: 67.92		CCNB2_HUMAN (9-307): 4.76e-82: 255: 17.21
+	At
		621661 CDKA1_ARATH (1-294): 6.8e-145: 410: 100.00		CCB12_ARATH (3-316): 1.11e-83: 261: 15.99
+	Hs
		625350 CDK2_HUMAN (1-293): 6.46e-149: 420: 67.92		CCNA1_HUMAN (16-312): 2.58e-77: 245: 15.39
+	At
		621660 CDKA1_ARATH (1-294): 6.8e-145: 410: 100.00		CCA23_ARATH (13-310): 1.18e-78: 248: 16.23
+	At
		621653 CDKA1_ARATH (1-294): 6.8e-145: 410: 100.00		CCA22_ARATH (1-314): 9.28e-77: 243: 15.72
+	At
		621643 CDKA1_ARATH (1-294): 6.8e-145: 410: 100.00		CCB11_ARATH (10-310): 2.01e-75: 239: 14.74
+	Hs
		590125 CDK2_HUMAN (1-293): 6.46e-149: 420: 67.92		CCNA2_HUMAN (15-305): 4.52e-71: 228: 16.04
+	At
		621646 CDKA1_ARATH (1-294): 6.8e-145: 410: 100.00		CCD11_ARATH (65-319): 5.57e-76: 238: 32.05
+	At
		48929 CDKA1_ARATH (1-294): 6.8e-145: 410: 100.00		CCA33_ARATH (24-300): 4.39e-75: 235: 14.58
+	Hs
		590162 CDK3_HUMAN (1-294): 1.39e-146: 415: 68.03		CCNA2_HUMAN (15-305): 4.52e-71: 228: 16.04
+	Hs
		624539 CDK2_HUMAN (1-293): 6.46e-149: 420: 67.92		CCNE1_HUMAN (5-317): 1.88e-68: 221: 15.71
+	Hs
		624573 CDK3_HUMAN (1-294): 1.39e-146: 415: 68.03		CCNE1_HUMAN (5-317): 1.88e-68: 221: 15.71
+	Rn
		981205 Q6P751_RAT (1-293): 1.25e-148: 420: 67.92		CCND2_RAT (11-308): 1.07e-65: 210: 16.94
+	Hs
		625155 CDK2_HUMAN (1-293): 6.46e-149: 420: 67.92		CCND2_HUMAN (11-316): 1.4e-64: 207: 17.53
+	At
		621648 CDKA1_ARATH (1-294): 6.8e-145: 410: 100.00		CCD31_ARATH (8-280): 1.06e-66: 215: 29.14
+	At
		621652 CDKA1_ARATH (1-294): 6.8e-145: 410: 100.00		CCD42_ARATH (24-256): 1.83e-65: 209: 29.96
+	At
		621647 CDKA1_ARATH (1-294): 6.8e-145: 410: 100.00		CCD21_ARATH (15-301): 2.29e-62: 203: 28.09
+	Xl
		193809 CDK2_XENLA (1-293): 9.28e-147: 415: 67.24		CCNE3_XENLA (65-230): 8.7e-39: 143: 24.56