HitPredict

Interactor 1: CDKA1 (P24100)
Cyclin-dependent kinase A-1 (CDKA;1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog A) (CDC2aAt)
Gene: CDKA-1

Interactor 2: CKS2 (Q9SJJ5)
Cyclin-dependent kinases regulatory subunit 2
Gene: CKS2

Species: Arabidopsis thaliana

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.81	1.00	0.900

Property	Details
Experiments	25521792, 17426018, 20407024, 20706207
Identification Methods	pull down, affinity chromatography technology, protein complementation assay, two hybrid, tandem affinity purification
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	CKS~Pkinase
Common GO terms	GO:0000307 - cyclin-dependent protein kinase holoenzyme complex GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 294 At			1 83
+	At
		188136 CDKA1_ARATH (1-294): 6.8e-145: 410: 100.00		CKS1_ARATH (1-71): 3.17e-40: 128: 94.37
+	Hs
		625283 CDK2_HUMAN (1-293): 6.46e-149: 420: 67.92		CKS1_HUMAN (3-76): 1.1e-35: 117: 67.57
+	Hs
		625164 CDK2_HUMAN (1-293): 6.46e-149: 420: 67.92		CKS2_HUMAN (3-76): 4.6e-34: 113: 66.22
+	Hs
		895413 CDK3_HUMAN (1-294): 1.39e-146: 415: 68.03		CKS1_HUMAN (3-76): 1.1e-35: 117: 67.57
+	Hs
		706796 CDK3_HUMAN (1-294): 1.39e-146: 415: 68.03		CKS2_HUMAN (3-76): 4.6e-34: 113: 66.22
+	At
		1103378 CKB12_ARATH (1-292): 2.87e-129: 371: 54.69		CKS2_ARATH (1-83): 4.33e-45: 141: 100.00
+	At
		1227962 CKB21_ARATH (1-291): 3.62e-129: 371: 53.51		CKS2_ARATH (1-83): 4.33e-45: 141: 100.00
+	At
		1321299 CDKD1_ARATH (2-293): 8.54e-128: 371: 47.26		CKS2_ARATH (1-83): 4.33e-45: 141: 100.00
+	At
		639376 CKB11_ARATH (1-292): 4.04e-129: 371: 54.07		CKS2_ARATH (1-83): 4.33e-45: 141: 100.00
+	Hs
		414843 CDK1_HUMAN (1-292): 6.73e-138: 392: 66.55		CKS1_HUMAN (3-76): 1.1e-35: 117: 67.57
+	Hs
		414778 CDK1_HUMAN (1-292): 6.73e-138: 392: 66.55		CKS2_HUMAN (3-76): 4.6e-34: 113: 66.22
+	Dm
		618415 CDK1_DROME (1-288): 3.84e-133: 380: 64.01		Q9VHN1_DROME (2-71): 2.92e-37: 121: 65.71
+	Ce
		712291 CDK1_CAEEL (1-291): 5.57e-129: 371: 56.86		CKS1_CAEEL (3-76): 1.06e-40: 130: 59.46
+	At
		188137 CKB11_ARATH (1-292): 4.04e-129: 371: 54.07		CKS1_ARATH (1-71): 3.17e-40: 128: 94.37
+	At
		188147 CKB12_ARATH (1-292): 2.87e-129: 371: 54.69		CKS1_ARATH (1-71): 3.17e-40: 128: 94.37
+	At
		188156 CKB21_ARATH (1-291): 3.62e-129: 371: 53.51		CKS1_ARATH (1-71): 3.17e-40: 128: 94.37
+	Dm
		618387 CDK1_DROME (1-288): 3.84e-133: 380: 64.01		CKS1_DROME (3-71): 4.92e-35: 115: 68.12
+	Hs
		895414 CDK5_HUMAN (1-293): 1.66e-131: 376: 55.78		CKS1_HUMAN (3-76): 1.1e-35: 117: 67.57
+	Sp
		383445 CDK1_SCHPO (1-291): 1.46e-130: 374: 60.74		CKS1_SCHPO (1-80): 1.02e-34: 115: 46.07
+	Hs
		706797 CDK5_HUMAN (1-293): 1.66e-131: 376: 55.78		CKS2_HUMAN (3-76): 4.6e-34: 113: 66.22