HitPredict

Interactor 1: PRTN3 (P24158)
Myeloblastin (EC 3.4.21.76) (AGP7) (C-ANCA antigen) (Leukocyte proteinase 3) (PR-3) (PR3) (Neutrophil proteinase 4) (NP-4) (P29) (Wegener autoantigen)
Gene: PRTN3

Interactor 2: ILEU (P30740)
Leukocyte elastase inhibitor (LEI) (Monocyte/neutrophil elastase inhibitor) (EI) (M/NEI) (Peptidase inhibitor 2) (PI-2) (Serpin B1)
Gene: SERPINB1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	1.00	0.799

Property	Details
Experiments	33961781, 12114510
Identification Methods	affinity chromatography technology, enzymatic study, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Serpin~Trypsin
Common GO terms	GO:0005576 - extracellular region GO:0005615 - extracellular space GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 256 Hs			1 379
+	Hs
		428671 TRY1_HUMAN (8-251): 9.12e-103: 300: 33.20		SPB8_HUMAN (1-379): 9.43e-160: 454: 51.98
+	Hs
		439065 ELNE_HUMAN (1-256): 8.71e-90: 268: 53.13		ILEU_HUMAN (1-379): 6.93e-169: 478: 100.00
+	Hs
		344162 PRTN3_HUMAN (1-256): 5.43e-109: 316: 100.00		A1AT_HUMAN (2-379): 5.31e-143: 413: 30.63
+	Hs
		719387 KLK13_HUMAN (5-255): 1.37e-93: 278: 28.99		SPB6_HUMAN (1-379): 2.61e-157: 448: 50.79
+	Hs
		714770 TRY3_HUMAN (15-251): 6.12e-98: 290: 33.87		SPB12_HUMAN (1-379): 1.14e-148: 428: 40.99
+	Hs
		589593 KLK2_HUMAN (10-251): 1.59e-89: 267: 30.83		SPB6_HUMAN (1-379): 2.61e-157: 448: 50.79
+	Mm
		430527 Q9Z1R9_MOUSE (11-250): 2.22e-103: 302: 36.58		A1AT1_MOUSE (3-379): 4.43e-141: 408: 31.41
+	Hs
		371463 KLKB1_HUMAN (17-255): 1.48e-97: 300: 27.06		IPSP_HUMAN (6-379): 6.86e-140: 405: 33.25
+	Hs
		344349 KLK13_HUMAN (5-255): 1.37e-93: 278: 28.99		AACT_HUMAN (4-379): 4.5e-146: 421: 34.47
+	Mm
		430524 ELNE_MOUSE (20-249): 8.84e-97: 285: 55.84		A1AT1_MOUSE (3-379): 4.43e-141: 408: 31.41
+	Hs
		371455 FA11_HUMAN (20-248): 5.29e-93: 287: 26.94		IPSP_HUMAN (6-379): 6.86e-140: 405: 33.25
+	Hs
		344265 ELNE_HUMAN (1-256): 8.71e-90: 268: 53.13		AACT_HUMAN (4-379): 4.5e-146: 421: 34.47
+	Hs
		344274 KLK2_HUMAN (10-251): 1.59e-89: 267: 30.83		AACT_HUMAN (4-379): 4.5e-146: 421: 34.47
+	Hs
		177775 TMPS2_HUMAN (1-248): 2.73e-89: 274: 27.14		A1AT_HUMAN (2-379): 5.31e-143: 413: 30.63
+	Hs
		344151 ELNE_HUMAN (1-256): 8.71e-90: 268: 53.13		A1AT_HUMAN (2-379): 5.31e-143: 413: 30.63
+	Hs
		341339 PLMN_HUMAN (25-248): 3.15e-89: 282: 35.42		PAI1_HUMAN (4-379): 1.07e-134: 392: 29.74
+	Hs
		397636 KLK2_HUMAN (10-251): 1.59e-89: 267: 30.83		IPSP_HUMAN (6-379): 6.86e-140: 405: 33.25
+	Hs
		421277 KLK13_HUMAN (5-255): 1.37e-93: 278: 28.99		GDN_HUMAN (3-379): 3.31e-132: 385: 32.46
+	Hs
		421257 KLK2_HUMAN (10-251): 1.59e-89: 267: 30.83		GDN_HUMAN (3-379): 3.31e-132: 385: 32.46
+	Hs
		439086 ELNE_HUMAN (1-256): 8.71e-90: 268: 53.13		NEUS_HUMAN (11-379): 2.06e-62: 207: 33.42