HitPredict

Interactor 1: PRTN3 (P24158)
Myeloblastin (EC 3.4.21.76) (AGP7) (C-ANCA antigen) (Leukocyte proteinase 3) (PR-3) (PR3) (Neutrophil proteinase 4) (NP-4) (P29) (Wegener autoantigen)
Gene: PRTN3

Interactor 2: EGFL8 (Q99944)
Epidermal growth factor-like protein 8 (EGF-like protein 8) (Vascular endothelial statin-2) (VE-statin-2)
Gene: EGFL8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	EGF~Trypsin
Common GO terms	GO:0005102 - signaling receptor binding GO:0005576 - extracellular region
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 256 Hs			1 293
+	Hs
		409568 HEPS_HUMAN (7-254): 3.26e-93: 282: 27.80		EGFL7_HUMAN (16-285): 3.48e-48: 163: 34.18
+	Hs
		178031 TMPS2_HUMAN (1-248): 2.73e-89: 274: 27.14		EGFL7_HUMAN (16-285): 3.48e-48: 163: 34.18
+	Hs
		1198216 TM11B_HUMAN (8-246): 2.66e-89: 272: 24.05		AGRE2_HUMAN (4-191): 2.54e-28: 116: 17.12
+	Hs
		1053512 TM11B_HUMAN (8-246): 2.66e-89: 272: 24.05		GAS6_HUMAN (13-193): 3.59e-18: 86.4: 18.33
+	Hs
		371464 KLKB1_HUMAN (17-255): 1.48e-97: 300: 27.06		FBN2_HUMAN (111-185): 9.29e-09: 58.2: 30.86
+	Hs
		1055016 TMPS4_HUMAN (5-246): 3.48e-92: 280: 26.54		FAT1_HUMAN (7-64): 2.74e-13: 72.1: 10.35
+	Mm
		378815 GRAB_MOUSE (23-250): 7.19e-90: 267: 35.98		NOTC1_MOUSE (26-217): 4.99e-15: 77.5: 15.81
+	Hs
		980428 TM11B_HUMAN (8-246): 2.66e-89: 272: 24.05		NOTC2_HUMAN (4-199): 2.38e-12: 69.4: 11.49
+	Hs
		296677 TMPS4_HUMAN (5-246): 3.48e-92: 280: 26.54		SLIT2_HUMAN (71-179): 1.2e-09: 60.9: 16.38
+	Hs
		1055020 KLK11_HUMAN (25-250): 6.76e-89: 266: 30.71		FAT1_HUMAN (7-64): 2.74e-13: 72.1: 10.35
+	Hs
		486154 GRAB_HUMAN (23-250): 1.88e-87: 261: 38.49		NOTC1_HUMAN (34-205): 6.3e-15: 77.1: 19.10
+	Hs
		177760 TMPS2_HUMAN (1-248): 2.73e-89: 274: 27.14		SLIT2_HUMAN (71-179): 1.2e-09: 60.9: 16.38
+	Hs
		439361 CATG_HUMAN (22-248): 1.63e-41: 144: 37.55		EGFL8_HUMAN (1-293): 6.97e-41: 145: 100.00
+	Hs
		621366 CMA1_HUMAN (23-248): 3.92e-46: 155: 40.25		FAT1_HUMAN (7-64): 2.74e-13: 72.1: 10.35
+	Mm
		93496 CFAD_MOUSE (10-245): 1.33e-33: 124: 34.52		E9Q440_MOUSE (111-176): 1.17e-22: 99.8: 40.85
+	Mm
		94698 CFAD_MOUSE (10-245): 1.33e-33: 124: 34.52		F2Z4A3_MOUSE (3-106): 3.26e-22: 98.6: 11.54
+	Hs
		621373 CMA1_HUMAN (23-248): 3.92e-46: 155: 40.25		FAT4_HUMAN (7-99): 1.14e-09: 61.3: 11.88
+	Mm
		371892 CFAD_MOUSE (10-245): 1.33e-33: 124: 34.52		FBLN7_MOUSE (63-186): 5.65e-15: 76.3: 20.86
+	Mm
		192824 CFAD_MOUSE (10-245): 1.33e-33: 124: 34.52		NOTC2_MOUSE (4-249): 1.77e-10: 63.6: 11.01
+	Mm
		372668 CFAD_MOUSE (10-245): 1.33e-33: 124: 34.52		SLIT2_MOUSE (71-179): 5.2e-09: 59: 16.38