HitPredict

Interactor 1: MCM3 (P24279)
DNA replication licensing factor MCM3 (EC 3.6.4.12) (Minichromosome maintenance protein 3)
Gene: MCM3

Interactor 2: MCM5 (P29496)
Minichromosome maintenance protein 5 (EC 3.6.4.12) (Cell division control protein 46)
Gene: MCM5

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.989

The method score is based on:

Property Details
Experiments 9315644, 8756666, 19910535, 23499444, 12060653, 25087873, 28191893, 25659432, 25172955, 32075754, 31728581, 18662997, 35614055, 33741931, 37968396, 22421151, 25313033, 19106085, 24692448, 21179020 and 3 others

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Identification Methods coimmunoprecipitation, two hybrid, anti tag coimmunoprecipitation, affinity chromatography technology, pull down, biochemical, tandem affinity purification, miniaturized immunoprecipitation, molecular sieving
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains MCM~MCM, MCM~MCM_lid, MCM~MCM_N, MCM~MCM_OB, MCM_N~MCM_N, MCM_N~MCM_OB, MCM_OB~MCM_OB
Common GO terms GO:0000727 - double-strand break repair via break-induced replication
GO:0000781 - chromosome, telomeric region
GO:0003682 - chromatin binding
GO:0003688 - DNA replication origin binding
GO:0003697 - single-stranded DNA binding
and 17 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 971
Sc

1 775
+ Sc
+ Sc
+ Mm
+ Hs
+ Hs
+ Dm
+ Sp
+ Mm
+ Hs
+ Mm
+ Sp
+ Hs
+ Hs
+ Dm
+ Hs
+ Sp
+ Dm
+ Dm
+ Sc
+ Sp

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Last updated: 15 Jul 2024