HitPredict

Interactor 1: MCM3 (P24279)
DNA replication licensing factor MCM3 (EC 3.6.4.12) (Minichromosome maintenance protein 3)
Gene: MCM3

Interactor 2: H3 (P61830)
Histone H3
Gene: HHT1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	22199229, 21179020
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0031298 - replication fork protection complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 971 Sc			1 136
+	Hs
		627235 MCM3_HUMAN (56-971): 0: 786: 40.54		H31_HUMAN (1-136): 3.24e-62: 188: 88.97
+	Mm
		935446 MCM2_MOUSE (60-765): 0: 682: 30.61		H31_MOUSE (1-136): 3.24e-62: 188: 88.97
+	Mm
		952736 MCM2_MOUSE (60-765): 0: 682: 30.61		H33_MOUSE (1-136): 1.25e-61: 187: 90.44
+	Mm
		952250 MCM2_MOUSE (60-765): 0: 682: 30.61		H32_MOUSE (1-136): 6.6e-61: 185: 88.97
+	Hs
		832357 MCM2_HUMAN (60-764): 0: 677: 30.65		H31_HUMAN (1-136): 3.24e-62: 188: 88.97
+	Hs
		832369 MCM2_HUMAN (60-764): 0: 677: 30.65		H33_HUMAN (1-136): 1.25e-61: 187: 90.44
+	Hs
		832495 MCM2_HUMAN (60-764): 0: 677: 30.65		H31T_HUMAN (1-136): 1.96e-61: 186: 86.03
+	Hs
		832541 MCM2_HUMAN (60-764): 0: 677: 30.65		H32_HUMAN (1-136): 6.6e-61: 185: 88.97
+	Hs
		708603 MCM5_HUMAN (31-809): 0: 662: 25.67		H31_HUMAN (1-136): 3.24e-62: 188: 88.97
+	Hs
		708605 MCM5_HUMAN (31-809): 0: 662: 25.67		H33_HUMAN (1-136): 1.25e-61: 187: 90.44
+	Hs
		708661 MCM5_HUMAN (31-809): 0: 662: 25.67		H31T_HUMAN (1-136): 1.96e-61: 186: 86.03
+	Hs
		708690 MCM5_HUMAN (31-809): 0: 662: 25.67		H32_HUMAN (1-136): 6.6e-61: 185: 88.97
+	Mm
		935450 Q3V122_MOUSE (57-806): 0: 659: 27.79		H31_MOUSE (1-136): 3.24e-62: 188: 88.97
+	Mm
		952743 Q3V122_MOUSE (57-806): 0: 659: 27.79		H33_MOUSE (1-136): 1.25e-61: 187: 90.44
+	Mm
		952257 Q3V122_MOUSE (57-806): 0: 659: 27.79		H32_MOUSE (1-136): 6.6e-61: 185: 88.97
+	Hs
		708677 MCM5_HUMAN (31-809): 0: 662: 25.67		H37_HUMAN (1-136): 6.09e-59: 180: 86.77
+	Hs
		708683 MCM5_HUMAN (31-809): 0: 662: 25.67		H3C_HUMAN (1-136): 8.2e-59: 179: 86.03
+	Hs
		708861 MCM7_HUMAN (57-806): 0: 652: 29.06		H31_HUMAN (1-136): 3.24e-62: 188: 88.97
+	Hs
		708865 MCM7_HUMAN (57-806): 0: 652: 29.06		H33_HUMAN (1-136): 1.25e-61: 187: 90.44
+	Hs
		828172 MCM2_HUMAN (60-764): 0: 677: 30.65		CENPA_HUMAN (9-133): 2.55e-40: 133: 47.73