HitPredict

Interactor 1: MCM3 (P24279)
DNA replication licensing factor MCM3 (EC 3.6.4.12) (Minichromosome maintenance protein 3)
Gene: MCM3

Interactor 2: CTF4 (Q01454)
DNA polymerase alpha-binding protein (Chromosome replication protein CHL15) (Chromosome transmission fidelity protein 4) (Protein POB1)
Gene: CTF4

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	0.60	0.745

Property	Details
Experiments	32075754, 31728581, 32585006, 25697176, 27397685, 31589141, 19913425, 37968396, 21179020
Identification Methods	affinity chromatography technology, pull down, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000727 - double-strand break repair via break-induced replication GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0006270 - DNA replication initiation GO:0031298 - replication fork protection complex and 1 others more... GO:0043596 - nuclear replication fork
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 971 Sc			1 927
+	Sc
		667620 MCM2_YEAST (64-753): 0: 638: 30.70		CTF4_YEAST (1-927): 0: 634: 95.09
+	Sc
		675548 MCM4_YEAST (31-814): 0: 621: 25.68		CTF4_YEAST (1-927): 0: 634: 95.09
+	Hs
		274331 MCM7_HUMAN (57-806): 0: 652: 29.06		WDHD1_HUMAN (4-924): 8.41e-166: 515: 15.49
+	Sc
		667882 MCM5_YEAST (94-569): 2.38e-88: 301: 35.70		CTF4_YEAST (1-927): 0: 634: 95.09
+	Hs
		709008 MCM7_HUMAN (57-806): 0: 652: 29.06		SNR40_HUMAN (170-475): 1.4e-45: 169: 8.80
+	Hs
		708826 MCM7_HUMAN (57-806): 0: 652: 29.06		LIS1_HUMAN (3-85): 1.17e-15: 82.1: 9.64
+	Dm
		832224 MCM2_DROME (60-763): 0: 633: 29.83		Q494K2_DROME (8-145): 2.66e-11: 69.7: 9.74
+	Sc
		667875 MCM5_YEAST (94-569): 2.38e-88: 301: 35.70		COPA_YEAST (441-741): 4.04e-11: 69.4: 9.09
+	Hs
		708496 MCM4_HUMAN (568-819): 1.4e-25: 116: 19.25		SNR40_HUMAN (170-475): 1.4e-45: 169: 8.80