HitPredict

Interactor 1: PRP22 (P24384)
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22 (EC 3.6.4.13)
Gene: PRP22

Interactor 2: PRP19 (P32523)
Pre-mRNA-processing factor 19 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase PRP19)
Gene: PRP19

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.50	0.629

Property	Details
Experiments	11884590, 37968396, 29146870, 20089683
Identification Methods	affinity chromatography technology, pull down, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1145 Sc			1 503
+	Sp
		144075 PRP22_SCHPO (1-1138): 0: 918: 44.27		PRP19_SCHPO (1-480): 1.74e-82: 265: 20.04
+	Sc
		589417 PRP2_YEAST (252-1113): 0: 837: 34.18		PRP19_YEAST (1-503): 7.56e-93: 293: 100.00
+	Hs
		1055513 DHX8_HUMAN (1-1137): 0: 949: 40.81		PRP19_HUMAN (284-502): 2.22e-40: 153: 9.78
+	Sp
		144124 PRP16_SCHPO (3-1145): 0: 819: 34.14		PRP19_SCHPO (1-480): 1.74e-82: 265: 20.04
+	Sp
		144117 CDC28_SCHPO (4-1113): 0: 762: 32.50		PRP19_SCHPO (1-480): 1.74e-82: 265: 20.04
+	Sc
		692324 PRP43_YEAST (416-1106): 0: 700: 45.80		PRP19_YEAST (1-503): 7.56e-93: 293: 100.00
+	Sp
		144077 DHX15_SCHPO (410-1129): 0: 716: 44.82		PRP19_SCHPO (1-480): 1.74e-82: 265: 20.04
+	Sc
		554207 PRP16_YEAST (217-1109): 0: 670: 35.31		PRP19_YEAST (1-503): 7.56e-93: 293: 100.00
+	Hs
		195393 DHX15_HUMAN (471-1112): 0: 746: 47.10		WDR5_HUMAN (262-502): 3.82e-53: 184: 13.64
+	Hs
		1268349 PRP16_HUMAN (105-1139): 0: 809: 35.69		FBW1A_HUMAN (330-502): 2.45e-27: 117: 7.51
+	Hs
		903167 DHX9_HUMAN (109-1144): 0: 683: 20.04		WDR5_HUMAN (262-502): 3.82e-53: 184: 13.64
+	Hs
		224824 DHX16_HUMAN (242-1114): 0: 780: 41.22		FBXW7_HUMAN (198-415): 3.45e-17: 86.8: 13.42
+	Hs
		195578 DHX15_HUMAN (471-1112): 0: 746: 47.10		FBW1A_HUMAN (330-502): 2.45e-27: 117: 7.51
+	Hs
		1332149 DHX35_HUMAN (437-1114): 0: 691: 45.10		PRP19_HUMAN (284-502): 2.22e-40: 153: 9.78
+	Hs
		197089 DHX33_HUMAN (462-1103): 0: 687: 42.24		PRP4_HUMAN (293-502): 1.86e-39: 151: 11.87
+	Hs
		994406 DHX9_HUMAN (109-1144): 0: 683: 20.04		FBW1A_HUMAN (330-502): 2.45e-27: 117: 7.51
+	Hs
		994278 DHX9_HUMAN (109-1144): 0: 683: 20.04		FBXW7_HUMAN (198-415): 3.45e-17: 86.8: 13.42