HitPredict

Interactor 1: PRP22 (P24384)
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22 (EC 3.6.4.13)
Gene: PRP22

Interactor 2: PRP46 (Q12417)
Pre-mRNA-splicing factor PRP46 (Complexed with CEF1 protein 1) (PRP nineteen-associated complex protein 50) (PRP19-associated complex protein 50) (Pre-mRNA-processing protein 46)
Gene: PRP46

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	29146870, 20089683
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0071013 - catalytic step 2 spliceosome
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1145 Sc			1 451
+	Zm
		18259 A0A1D6H4I5_MAIZE (111-1135): 0: 920: 44.77		A0A1D6J4G2_MAIZE (1-337): 2.49e-83: 268: 16.53
+	Sc
		589467 PRP2_YEAST (252-1113): 0: 837: 34.18		PRP46_YEAST (1-451): 2.96e-105: 321: 100.00
+	Hs
		1055447 DHX8_HUMAN (1-1137): 0: 949: 40.81		SNR40_HUMAN (11-292): 1.46e-58: 197: 19.93
+	Hs
		209435 DHX8_HUMAN (1-1137): 0: 949: 40.81		PLRG1_HUMAN (7-167): 1.13e-17: 87.1: 10.41
+	Sc
		859466 PRP43_YEAST (416-1106): 0: 700: 45.80		PRP46_YEAST (1-451): 2.96e-105: 321: 100.00
+	Hs
		1268324 PRP16_HUMAN (105-1139): 0: 809: 35.69		SNR40_HUMAN (11-292): 1.46e-58: 197: 19.93
+	Sc
		554258 PRP16_YEAST (217-1109): 0: 670: 35.31		PRP46_YEAST (1-451): 2.96e-105: 321: 100.00
+	Hs
		224827 DHX16_HUMAN (242-1114): 0: 780: 41.22		SNR40_HUMAN (11-292): 1.46e-58: 197: 19.93
+	Sc
		630874 PRP43_YEAST (416-1106): 0: 700: 45.80		NLE1_YEAST (6-334): 1.12e-83: 268: 18.54
+	Hs
		224824 DHX16_HUMAN (242-1114): 0: 780: 41.22		FBXW7_HUMAN (6-247): 5.05e-48: 176: 16.14
+	Hs
		195393 DHX15_HUMAN (471-1112): 0: 746: 47.10		WDR5_HUMAN (4-209): 1.3e-44: 160: 15.28
+	Hs
		1288306 DHX35_HUMAN (437-1114): 0: 691: 45.10		SNR40_HUMAN (11-292): 1.46e-58: 197: 19.93
+	Hs
		994278 DHX9_HUMAN (109-1144): 0: 683: 20.04		FBXW7_HUMAN (6-247): 5.05e-48: 176: 16.14
+	Hs
		903167 DHX9_HUMAN (109-1144): 0: 683: 20.04		WDR5_HUMAN (4-209): 1.3e-44: 160: 15.28
+	Hs
		929414 DHX9_HUMAN (109-1144): 0: 683: 20.04		RACK1_HUMAN (261-439): 3.85e-30: 120: 20.21
+	Hs
		209480 DHX35_HUMAN (437-1114): 0: 691: 45.10		PLRG1_HUMAN (7-167): 1.13e-17: 87.1: 10.41